阿爾茨海默病的發(fā)病機(jī)制復(fù)雜，與多種因素有關(guān)。二苯乙烯苷是何首烏中主要活性成分，可通過抑制β淀粉樣蛋白生成和沉積、抑制α-突觸核蛋白聚集、減少Tau蛋白磷酸化、減輕炎癥反應(yīng)、抑制神經(jīng)元凋亡、增強(qiáng)抗氧化能力、增強(qiáng)神經(jīng)突觸可塑性治療阿爾茨海默病?？偨Y(jié)了二苯乙烯苷治療阿爾茨海默病的藥理作用研究進(jìn)展，為二苯乙烯苷的臨床應(yīng)用提供循證支持。

The pathogenesis of Alzheimer's disease is complex and related to multiple factors. Stilbene glycoside is the main active ingredient in Polygoni Multiflori Radix. Stilbene glycoside can treat Alzheimer's disease by inhibiting the generation and deposition of β-amyloid protein, inhibiting the aggregation of α-synuclein, reducing Tau protein phosphorylation, alleviating inflammatory response, inhibiting neuronal apoptosis, enhancing antioxidant capacity, and enhancing synaptic plasticity. This article summarizes the pharmacological research progress of stilbene glycoside in treatment of Alzheimer's disease, providing evidence-based support for the clinical application of stilbene glycoside.

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北京市醫(yī)院管理中心重點(diǎn)醫(yī)學(xué)專業(yè)發(fā)展計(jì)劃建設(shè)項(xiàng)目（ZYLX202132）