[關(guān)鍵詞]
[摘要]
益母草堿是益母草中特有的生物堿，具有多種生物學(xué)功能，對(duì)多個(gè)臟器均有不同的作用。益母草堿具有抗氧化應(yīng)激、抗炎、抗纖維化、抗細(xì)胞凋亡、調(diào)節(jié)代謝、調(diào)節(jié)血管、調(diào)節(jié)自噬的藥理作用，用于心血管系統(tǒng)疾病、神經(jīng)系統(tǒng)疾病、類風(fēng)濕性關(guān)節(jié)炎、骨代謝疾病和代謝類疾病。總結(jié)了益母草堿的藥理作用和臨床應(yīng)用研究進(jìn)展，為益母草堿在臨床治療中的應(yīng)用提供更多依據(jù)。
[Key word]
[Abstract]
Leonurine, a specific alkaloid isolated from Leonuri Herba, has multiple biological functions and different effects on multiple organs. Leonurine have pharmacological effects of antioxidant stress, anti-inflammation, anti-fibrosis, anti-apoptosis, regulating metabolism, regulating blood vessels, and regulating autophagy. It is used for cardiovascular diseases, neurological diseases, rheumatoid arthritis, bone metabolism diseases, and metabolic diseases. This article summarizes research progress of the pharmacological effects and clinical application of leonurine, providing more basis for the application of leonurine in clinical treatment.
[中圖分類號(hào)]
R285
[基金項(xiàng)目]
澳門科技發(fā)展基金項(xiàng)目FDCT（0012/2021/AMJ，0001/2024/RDP，0001/2024/AKP，0092/2022/A2，0144/2022/A3）；廣西壯族自治區(qū)衛(wèi)生健康委一般項(xiàng)目（S2024074）；桂林市科技計(jì)劃項(xiàng)目（20210227-9-4，20212E422580）；廣西壯族自治區(qū)南溪山醫(yī)院科研項(xiàng)目（NY2019007）
