白血病是造血系統(tǒng)中最常見(jiàn)的惡性克隆性疾病，已成為威脅全球人類(lèi)健康的重大疾病。中藥萜類(lèi)化合物為廣泛存在的天然異戊二烯代謝產(chǎn)物，具有顯著生物活性。中藥萜類(lèi)化合物抗白血病作用主要通過(guò)調(diào)控多種信號(hào)通路誘導(dǎo)細(xì)胞凋亡、抑制細(xì)胞增殖、細(xì)胞性鐵死亡和促進(jìn)細(xì)胞分化等關(guān)鍵機(jī)制實(shí)現(xiàn)。總結(jié)了中藥萜類(lèi)化合物抗白血病的藥理作用研究進(jìn)展，旨在為中藥治療白血病提供依據(jù)和研究方向。

Leukemia is the most common malignant clonal disease in the hematopoietic system, and has become a major disease threatening global human health. Traditional Chinese medicine terpenoids are widely natural isoprene metabolites, with significant biological activity. The anti-leukemia effect of traditional Chinese medicine terpenoids is mainly achieved through key mechanisms, such as regulating multiple signaling pathways to induce cell apoptosis, inhibit cell proliferation, induce ferroptosis, and promote cell differentiation. This article summarizes the research progress on the pharmacological effects of traditional Chinese medicine terpenoids on leukemia, aiming to provide a basis and research direction for treatment of leukemia with traditional Chinese medicine.

R977

國(guó)家重點(diǎn)研發(fā)計(jì)劃項(xiàng)目（2018YFC1707100）；黑龍江省“頭雁”團(tuán)隊(duì)項(xiàng)目（黑龍江省頭雁行動(dòng)領(lǐng)導(dǎo)小組文件[2019]5號(hào)）