目的 探討四妙丸聯(lián)合硫酸羥氯喹治療濕熱痹阻型類風(fēng)濕性關(guān)節(jié)炎的臨床療效。方法 選取2022年1月—2025年1月新疆維吾爾自治區(qū)人民醫(yī)院收治的濕熱痹阻型類風(fēng)濕性關(guān)節(jié)炎患者110例。按照隨機(jī)單雙數(shù)法均分為對(duì)照組和治療組，各55例。對(duì)照組患者給予硫酸羥氯喹片口服治療，0.2 g/次，2次/d。治療組患者在對(duì)照組的基礎(chǔ)上，給予四妙丸口服治療，6 g/次，2次/d。兩組患者療程均為12周。觀察兩組臨床療效，比較兩組患者治療前后中醫(yī)證候積分、類風(fēng)濕性關(guān)節(jié)炎簡(jiǎn)化疾病活動(dòng)指數(shù)（SDAI）、健康評(píng)價(jià)調(diào)查表（HAQ）評(píng)分、關(guān)節(jié)壓痛數(shù)（TJC）、關(guān)節(jié)腫脹數(shù)（SJC）、視覺模擬疼痛（VAS）評(píng)分以及紅細(xì)胞沉降率（ESR）、類風(fēng)濕因子（RF）、抗環(huán)瓜氨酸肽（CCP）抗體、C反應(yīng)蛋白（CRP）、白細(xì)胞介素-6（IL-6）水平。結(jié)果 治療組總有效率94.55%，要顯著高于對(duì)照組總有效率78.18%（P＜0.05）。治療后，兩組患者中醫(yī)證候積分、SDAI評(píng)分、TJC、SJC、HAQ評(píng)分和VAS評(píng)分均顯著降低（P＜0.05），且治療組要明顯優(yōu)于對(duì)照組（P＜0.05）。治療后，兩組患者ESR、RF、抗CCP抗體、CRP、IL-6水平均顯著降低（P＜0.05），且治療組要明顯優(yōu)于對(duì)照組（P＜0.05）。結(jié)論 四妙丸聯(lián)合硫酸羥氯喹治療濕熱痹阻型類風(fēng)濕性關(guān)節(jié)炎患者臨床療效良好，能夠減輕患者疼痛癥狀和體征，降低關(guān)節(jié)炎癥反應(yīng)，提高患者生活質(zhì)量。

Objective To investigate the clinical efficacy of Simiao Pills combined with hydroxychloroquine sulfate in treatment of damp-heat obstruction type rheumatoid arthritis. Methods A total of 110 patients with damp-heat obstruction type rheumatoid arthritis admitted to the People’s Hospital of Xinjiang Uygur Autonomous Region from January 2022 to January 2025 were selected. According to the random odd-even number method, they were evenly divided into control group and treatment group, with 55 cases in each group. Patients in control group were po administered with Hydroxychloroquine Sulfate Tablets, 0.2 g each time, twice daily. Patients in treatment group were po administered with Simiao Pills on basis of control group, 6 g each time, twice daily. The treatment course for both groups of patients was 12 weeks. The clinical efficacy of two groups was observed, and TCM syndrome score, SDAI score, HAQ scores, number of joint tenderness (TJC), number of joint swelling (SJC), VAS scores, ESR, RF, anti-CCP antibody, CRP, and IL-6 of two groups of patients before and after treatment were compared. Results The total effective rate of the treatment group was 94.55%, which was significantly higher than that of the control group (78.18%, P < 0.05). After treatment, the TCM syndrome scores, SDAI scores, TJC, SJC, HAQ scores, and VAS scores of both groups were significantly decreased (P < 0.05), and the treatment group was significantly better than control group (P < 0.05). After treatment, the levels of ESR, RF, anti-CCP antibody, CRP, and IL-6 in both groups were significantly decreased (P < 0.05), and the treatment group was significantly better than those in control group (P < 0.05). Conclusion Simiao Pills combined with hydroxychloroquine sulfate has good clinical efficacy in treatment of damp-heat obstruction type rheumatoid arthritis, and can alleviate patients’ pain symptoms and signs, reduce joint inflammatory responses, which can improve patients’ life quality.

R977

新疆維吾爾自治區(qū)自然科學(xué)基金資助項(xiàng)目（2024D01C97）；新疆維吾爾自治區(qū)人民醫(yī)院院級(jí)課題（20240247）