目的 探討紅金消結(jié)片聯(lián)合米非司酮片治療卵巢囊腫的臨床療效。方法 將2023年9月—2024年11月在上海市嘉定區(qū)南翔醫(yī)院就診的女性卵巢囊腫患者共計(jì)102例納入研究，按隨機(jī)數(shù)字表法將所有患者分為對(duì)照組和治療組，每組51例。對(duì)照組口服米非司酮片，1片/次，1次/d。治療組在對(duì)照組基礎(chǔ)上口服紅金消結(jié)片，4片/次，3次/d。兩組連續(xù)治療3個(gè)月。比較兩組患者的治療療效、痛經(jīng)癥狀、囊腫最大截面積、血清指標(biāo)。結(jié)果 治療組治愈率（80.39%）明顯高于對(duì)照組（62.75%），組間比較差異顯著（P＜0.05）。兩組治療后的痛經(jīng)嚴(yán)重程度評(píng)分、發(fā)作時(shí)間評(píng)分均顯著減?。?i>P＜0.05）；治療組治療后的痛經(jīng)嚴(yán)重程度評(píng)分、發(fā)作時(shí)間評(píng)分低于對(duì)照組（P＜0.05）。兩組治療后的囊腫最大截面積明顯縮小（P＜0.05），治療組治療后囊腫最大截面積小于對(duì)照組（P＜0.05）。兩組治療后的血清熱休克蛋白70（HSP-70）、腫瘤壞死因子-α（TNF-α）、糖類抗原125（CA125）水平顯著降低（P＜0.05），且治療組治療后血清HSP-70、TNF-α、CA125水平低于對(duì)照組（P＜0.05）。兩組治療后的血清抗繆勒管激素（AMH）、卵泡刺激素（FSH）、促黃體生成素（LH）水平均低于治療前（P＜0.05），且治療組治療后血清AMH、FSH、LH水平低于對(duì)照組（P＜0.05）。結(jié)論 紅金消結(jié)片聯(lián)合米非司酮片可提高卵巢囊腫的臨床療效，降低痛經(jīng)程度和囊腫最大截面積，減輕炎癥反應(yīng)，調(diào)節(jié)性激素水平。

Objective To investigate the clinical efficacy of Hongjin Xiaojie Tablets combined with Mifepristone Tablets in treatment of ovarian cysts. Methods A total of 102 female ovarian cyst patients who visited Shanghai Jiading Nanxiang Hospital from September 2023 to November 2024 were included in the study. All patients were divided into control group and treatment group using a random number table method, with 51 patients in each group. The control group took Mifepristone Tablets orally, 1 tablets/time, once daily. The treatment group took Hongjin Xiaojie Tablets orally on the basis of the control group, 4 tablets/time, 3 times daily. Both groups were treated continuously for 3 months. The treatment efficacy, dysmenorrhea symptoms, maximum cross-sectional area of cysts, and serum indicators were compared between two groups of patients. Results The cure rate of the treatment group (80.39%) was significantly higher than that of the control group (62.75%), and the difference was significant between the groups (P < 0.05). The severity score and onset time score of dysmenorrhea significantly decreased in two groups after treatment (P < 0.05), the severity score and onset time score of dysmenorrhea in the treatment group were lower than those in the control group after treatment (P < 0.05). After treatment, the maximum cross-sectional area of the cysts in two groups significantly decreased (P < 0.05), and the maximum cross-sectional area of the cysts in the treatment group was smaller than that in the control group (P < 0.05). After treatment, the serum levels of HSP-70, TNF-α, and CA125 in two groups were significantly reduced (P < 0.05), and the serum levels of HSP-70, TNF-α, and CA125 in the treatment group were lower than those in the control group (P < 0.05). The serum levels of AMH, FSH, and LH in two groups were significantly reduced after treatment (P < 0.05), and the serum levels of AMH, FSH, and LH in the treatment group were lower than those in the control group after treatment (P < 0.05). Conclusion The combination of Hongjin Xiaojie Tablets and Mifepristone Tablets can improve the clinical efficacy of ovarian cysts, reduce the degree of dysmenorrhea and the maximum cross-sectional area of cysts, alleviate inflammatory reactions, and regulate hormone levels.

R984

上海市嘉定區(qū)衛(wèi)生健康委員會(huì)科研課題（2021-KY-06）