目的 觀察金銀花口服液聯(lián)合氨溴特羅口服溶液治療小兒支氣管肺炎的臨床療效。方法 選取2022年1月—2024年12月十堰市太和醫(yī)院收治的150例小兒支氣管肺炎患兒，利用組間匹配原則將患者分為對(duì)照組75例和治療組75例。對(duì)照組給予鹽酸氨溴特羅口服液，≤1歲，5 mL/次；1歲＜患兒年齡≤3歲，7.5 mL/次；3歲＜患兒年齡≤5歲，10 mL/次；＞5歲：15 mL/次，均2次/d。治療組在對(duì)照組治療方案基礎(chǔ)上口服金銀花口服液，≤3歲，10 mL/次，2次/d；3歲＜患兒年齡≤7歲，10 mL/次，3次/d。兩組均連續(xù)治療12 d。觀察兩組的臨床療效和臨床癥狀消失時(shí)間，比較治療前后血清炎性因子和白細(xì)胞（WBC）水平。結(jié)果 治療后，治療組總有效率是97.33%，顯著高于對(duì)照組的86.67%（P＜0.05）。與對(duì)照組相比，治療組咳嗽及啰音消失、體溫及胸片恢復(fù)正常時(shí)間均顯著較短（P＜0.05）。治療后，兩組C反應(yīng)蛋白（CRP）、白細(xì)胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）、淀粉樣蛋白（SAA）、WBC均較治療前下降（P＜0.05），且治療組CRP、IL-6、TNF-α、SAA、WBC低于對(duì)照組（P＜0.05）。結(jié)論 金銀花口服液聯(lián)合氨溴特羅口服溶液治療小兒支氣管肺炎利于提高患兒治療效果，縮短臨床癥狀改善時(shí)間，改善機(jī)體炎癥狀態(tài)。

Objective To observe the effects of Jinyinhua Oral Liquid combined with ambroxol in treatment of bronchopneumonia in children. Methods A total of 150 children with bronchopneumonia admitted to Taihe Hospital in Shiyan City from January 2022 to December 2024 were selected. The patients were divided into a control group of 75 cases and a treatment group of 75 cases by using the principle of matching between groups. Children in control group were given Ambroxol Hydrochloride and Clenbuterol Hydrochloride Oral Solution, for children ≤1 year old, 5 mL each time. For children aged 1 year to 3 years, 7.5 mL each time, for children aged 3 to 5 years old, 10 mL each time, for children over 5 years old, 15 mL each time, twice daily. Children in treatment group orally took Jinyinhua Oral Liquid on basis of treatment plan of control group. For children ≤ 3 years old, 10 mL each time, twice daily, for children aged 3 to 7 years old, 10 mL each time, 3 times daily. Both groups were treated continuously for 12 d. The clinical efficacy and the disappearance time of clinical symptoms of two groups were observed, and the levels of serum inflammatory factors and white blood cells (WBC) in two groups before and after treatment were compared. Results After treatment, the total effective rate of the treatment group was 97.33%, significantly higher than 86.67% of the control group (P < 0.05). Compared with control group, the time for cough and rales to disappear, body temperature and chest X-ray to return to normal in treatment group was significantly shorter (P < 0.05). After treatment, CRP, IL-6, TNF-α, SAA, and WBC in both groups decreased compared with those before treatment (P < 0.05), and CRP, IL-6, TNF-α, SAA, and WBC in treatment group were lower than those in control group (P < 0.05). Conclusion Jinyinhua Oral Liquid combined with ambroxol in treatment of bronchopneumonia in children can improve the therapeutic effect of children, shorten the time for improvement of clinical symptoms, and improve the inflammatory state of body.

R974;R985

湖北省重點(diǎn)研發(fā)計(jì)劃項(xiàng)目（2022SF-235）