目的 探討?zhàn)B正合劑聯(lián)合利可君片治療化療后白細胞減少癥的臨床療效。方法 納入2023年3月—2025年3月亳州市人民醫(yī)院收治的82例化療后白細胞減少癥患者，隨機分為對照組和治療組，每組各41例。對照組餐后30 min口服利可君片，20 mg/次，3次/d。在對照組基礎上，治療組晨起空腹及睡前口服養(yǎng)正合劑，20 mL/次，3次/d。兩組患者均連續(xù)給藥14 d。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀改善時間，簡式抑郁–焦慮–壓力量表（DASS-21）、中文版癌癥自我管理效能感量表（C-SUPPH）和36項健康調查簡表（SF-36）評分，及白細胞計數(shù)（WBC）、中性粒細胞絕對計數(shù)（ANC）和血清粒細胞集落刺激因子（G-CSF）水平。結果 治療后，治療組總有效率（95.12%）明顯高于對照組（80.49%，P＜0.05）。治療后，與對照組相比，治療組神疲乏力、頭暈目眩、五心煩熱等癥狀改善時間均明顯縮短（P＜0.05）。治療后，兩組DASS-21評分明顯減少，C-SUPPH和SF-36評分明顯增加（P＜0.05）；且治療組各評分優(yōu)于對照組（P＜0.05）。治療后，治療后，兩組WBC、ANC和血清G-CSF水平均顯著升高（P＜0.05），且治療組各指標水平明顯高于對照組（P＜0.05）。結論 化療后白細胞減少癥采用養(yǎng)正合劑聯(lián)合利可君片治療，安全性良好，能有效促進WBC、ANC回升，減輕軀體癥狀，改善心身狀態(tài)，提升患者自我管理能力與生活質量。

Objective To investigate the clinical efficacy of Yangzheng Mixture combined with Leucogen Tablets in treatment of leukopenia after chemotherapy. Methods Patients (82 cases) with leukopenia after chemotherapy in Bozhou People′s Hospital from March 2023 to March 2025 were randomly divided into control and treatment group, and each group had 41 cases. Patient in the control group were po administered with Leucogen Tablets 30 min after meals, 20 mg/time, three times daily. Patient in the treatment group were po administered with Yangzheng Mixture on the basis of the control group, 20 mL/time, three times daily. Patient in two groups were treated for 14 d. After treatment, the clinical evaluations were evaluated, and the symptom improvement time, the scores of DASS-21, C-SUPPH and SF-36, and the levels of WBC, ANC and G-CSF in two groups before and after treatment were compared. Results After treatment, the total effective rate in the treatment group (95.12%) was significantly higher than that in the control group (80.49%, P < 0.05). After treatment, compared with the control group, the improvement time for symptoms such as fatigue, dizziness, and five upset fever in the treatment group was significantly shortened (P < 0.05). After treatment, the DASS-21 scores of both groups decreased significantly, while the C-SUPPH and SF-36 scores increased significantly (P < 0.05). And the treatment group was superior to the control group (P < 0.05). After treatment, the levels of WBC, ANC and serum G-CSF in two groups were significantly increased (P < 0.05), and the levels of indicators in the treatment group were significantly higher than those in the control group (P < 0.05). Conclusion Yangzheng Mixture combined with Leucogen Tablets is safe in the treatment of leukopenia after chemotherapy, which can effectively promote the recovery of WBC and ANC, reduce physical symptoms, improve psychosomatic state, and improve the self-management ability and quality of life of patients.

R977

安徽省衛(wèi)生健康科研項目（AHWJ2023A20189）