目的 探討牛黃寧宮片聯(lián)合布南色林治療精神分裂癥的臨床療效。方法 選取2022年3月—2024年12月在河北省第六人民醫(yī)院治療的精神分裂癥患者120例，隨機(jī)分為對(duì)照組和治療組，每組各60例。對(duì)照組口服布南色林片，起始劑量4 mg/次，2次/d，2周內(nèi)根據(jù)患者病情及耐受情況，逐漸增至8～16 mg/d。在對(duì)照組的基礎(chǔ)上，治療組口服牛黃寧宮片，5片/次，3次/d。兩組患者治療8周。觀察兩組患者臨床療效，比較治療前后兩組患者陽(yáng)性和陰性綜合征量表（PANSS）、臨床總體印象量表–病情嚴(yán)重程度（CGI-SI）、個(gè)體和社會(huì)功能量表（PSP）、健康狀況調(diào)查問(wèn)卷（SF-36）評(píng)分和副反應(yīng)量表（TESS）評(píng)分，及不良反應(yīng)發(fā)生情況。結(jié)果 治療后，治療組總有效率為95.00%，明顯高于對(duì)照組總有效率（83.33%，P＜0.05）。治療后，兩組PANSS和CGI-SI評(píng)分均低于組內(nèi)治療前，而PSP、SF-36評(píng)分高于組內(nèi)治療前（P＜0.05），且治療組PANSS、CGI-SI、PSP、SF-36評(píng)分明顯好于同期對(duì)照組（P＜0.05）。治療后，治療組TESS評(píng)分顯著低于對(duì)照組（P＜0.05），治療組靜坐不能、失眠、便秘的發(fā)生率顯著低于對(duì)照組（P＜0.05）。結(jié)論 針對(duì)精神分裂癥采用牛黃寧宮片聯(lián)合布南色林治療，可獲得較滿意的療效，不僅能減輕患者的精神癥狀和病情嚴(yán)重程度，還可改善社會(huì)功能和生活質(zhì)量，且不良反應(yīng)更輕。

Objective To investigate the clinical efficacy of Niuhuang Ninggong Tablets combined with blonanserin in treatment of schizophrenia. Methods Patients (120 cases) with schizophrenia in the Sixth People’s Hospital of Hebei Province from March 2022 to December 2024 were randomly divided into control and treatment group, and each had 60 cases. Patient in the control group were po administered with Blonanserin Tablets, the starting dose was 4 mg/time, twice daily, and gradually increased to 8 — 16 mg/d within 2 weeks according to the patient's condition and tolerance. Patient in the treatment group were po administered with Niuhuang Ninggong Tablets on the basis of the control group, 5 tablets/time, three times daily. Patient in two groups were treated for 8 weeks. After treatment, the clinical evaluations were evaluated, and the scores of PANSS, CGI-SI, PSP, SF-36 and TESS, and adverse reactions in two groups before and after treatment were compared. Results After treatment, the total effective rate in the treatment group was 95.00%, which was significantly higher than that in the control group (83.33%, P < 0.05). After treatment, the PANSS and CGI-SI scores in two groups were lower than those before treatment in the group, while the PSP and SF-36 scores were higher than those before treatment in the group (P < 0.05). The PANSS, CGI-SI, PSP and SF-36 scores in the treatment group were significantly better than those in the control group during the same period (P < 0.05). After treatment, the TESS score in the treatment group was significantly lower than that in the control group (P < 0.05), the incidence of akathisia, insomnia, and constipation in the treatment group was significantly lower than that in the control group (P < 0.05). Conclusion Treatment of schizophrenia with Niuhuang Ninggong Tablets combined with blonanserin can achieve satisfactory curative effects, which can not only alleviate the patient′s mental symptoms and severity of the condition, but also improve social function and quality of life, and the side effects are milder.

R971

河北省醫(yī)學(xué)科學(xué)研究課題計(jì)劃（20211463）