目的 探討丹紅注射液聯(lián)合阿司匹林及氯吡格雷治療短暫性腦缺血發(fā)作的臨床療效。方法 納入2020年1月—2024年12月中國人民解放軍聯(lián)勤保障部隊(duì)第九二八醫(yī)院收治的短暫性腦缺血發(fā)作患者96例，隨機(jī)分為對照組和治療組，每組各48例。對照組給予雙抗療法，口服阿司匹林腸溶片100 mg/次，硫酸氫氯吡格雷片75 mg/次，1次/d。在對照基礎(chǔ)上，治療組靜脈滴注丹紅注射液，40 mL加入生理鹽水250 mL中，1次/d。兩組患者用藥1周。觀察兩組患者臨床療效，比較治療前后兩組患者疾病發(fā)作持續(xù)時(shí)間和頻率，凝血指標(biāo)凝血酶時(shí)間（TT）、凝血酶原時(shí)間（PT）、纖維蛋白原（FIB）和活化的部分凝血活酶時(shí)間（APTT），及血小板分布寬度（PDW）、血小板與淋巴細(xì)胞比值（PLR）、平均血小板體積（MPV）和血清C反應(yīng)蛋白（CRP）水平。結(jié)果 治療后，治療組總有效率（93.75%）明顯高于對照組（79.17%，P＜0.05）。治療后，兩組疾病發(fā)作持續(xù)時(shí)間和頻率均減少（P＜0.05），且治療組均少于對照組（P＜0.05）。治療后，兩組凝血指標(biāo)TT、PT、APTT顯著延長，而FIB下降（P＜0.05），且治療組凝血指標(biāo)變化比對照組更顯著（P＜0.05）。治療后，兩組PDW、PLR、MPV和血清CRP水平均顯著下降（P＜0.05），且治療組指標(biāo)水平降低幅度比對照組更顯著（P＜0.05）。結(jié)論 針對短暫性腦缺血發(fā)作聯(lián)合應(yīng)用丹紅注射液與阿司匹林及氯吡格雷，安全性較佳，能有效抑制凝血亢進(jìn)和血栓形成，阻斷炎癥級聯(lián)反應(yīng)，進(jìn)一步控制疾病發(fā)作。

Objective To investigate the clinical efficacy of Danhong Injection combined with aspirin and clopidogrel in treatment of transient ischemic attack. Methods Patients (96 cases) with transient ischemic attack in 928 Hospital of PLA Joint Logistics Support Force from January 2020 to December 2024 were randomly divided into control and treatment group, and each group had 48 cases. Patient in the control group were administered with dual resistance therapy, they were po administered with Aspirin Enteric-coated Tablets 100 mg/time, Clopidogrel Bisulfate Tablets for 75 mg/time, once daily. Patient in the treatment group were iv administered with Danhong Injection on the basis of the control group, 40 mL added into normal saline 250 mL, once daily. Patient in two groups were treated for 1 week. After treatment, the clinical evaluations were evaluated, and the duration and frequency of transient ischemic disease attacks, coagulation indicators TT, PT, APTT and FIB, and the levels of PDW, PLR, MPV and serum CRP in two groups before and after treatment were compared. Results After treatment, the total effective rate in the treatment group (93.75%) was significantly higher than that in the control group (79.17%, P < 0.05). After treatment, the duration and frequency of disease attacks were decreased in two groups (P < 0.05), and which in the treatment group was less than that in the control group (P < 0.05). After treatment, the coagulation indicators TT, PT, and APTT were significantly prolonged in two groups, while the FIB content was decreased (P < 0.05). The changes of coagulation indicators in the treatment group were more significant than that in the control group (P < 0.05). After treatment, the levels of PDW, PLR, MPV and serum CRP in two groups were decreased significantly (P < 0.05), and the decrease levels in the treatment group was more significant than that in the control group (P < 0.05). Conclusion The combined use of Danhong Injection, aspirin, and clopidogrel for transient ischemic attacks has better safety and can effectively inhibit coagulation and thrombosis, block the inflammatory cascade reaction, and further control disease onset.

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