動(dòng)脈粥樣硬化是導(dǎo)致多種心血管疾病的重要原因。目前臨床治療動(dòng)脈粥樣硬化的藥物包括降脂藥物、抗血小板藥、降壓藥物、血管擴(kuò)張劑等。丹皮酚具有多種活性，可通過減輕炎癥反應(yīng)、減輕氧化應(yīng)激反應(yīng)、抑制血管內(nèi)皮細(xì)胞凋亡、抑制內(nèi)皮–間充質(zhì)轉(zhuǎn)化進(jìn)程、恢復(fù)血管平滑肌細(xì)胞活性、調(diào)節(jié)血脂、減輕脂質(zhì)積累、改善血液流變學(xué)發(fā)揮防治動(dòng)脈粥樣硬化的作用?？偨Y(jié)了丹皮酚抗動(dòng)脈粥樣硬化的藥理作用研究進(jìn)展，為丹皮酚治療動(dòng)脈粥樣硬化的應(yīng)用提供參考。

Atherosclerosis is an important cause of many cardiovascular diseases. At present, the drugs for clinical treatment of atherosclerosis include lipid-lowering drugs, antiplatelet drugs, antihypertensive drugs, vasodilators, etc. Paeonol has various activities, which can prevent and treat atherosclerosis by alleviating inflammatory response, reducing oxidative stress response, inhibiting endothelial cell apoptosis, suppressing endothelial-mesenchymal transition process, restoring vascular smooth muscle cell activity, regulating blood lipids, reducing lipid accumulation, and improving hemorheology. This article summarized the research progress of the pharmacological effects of paeonol against atherosclerosis, providing a reference for the application of paeonol in treatment of atherosclerosis.

R285.5;R972

濰坊市科技發(fā)展計(jì)劃項(xiàng)目（WFWSJK-2023-322）