膿毒癥是感染引發(fā)的全身炎癥反應(yīng)，常導(dǎo)致多器官功能衰竭，其中肺損傷是早期且嚴(yán)重的并發(fā)癥，臨床治療手段有限。丹參酮Ⅱ_A是由丹參中提取的二萜醌類化合物，可通過(guò)減輕炎癥反應(yīng)，降低氧化應(yīng)激反應(yīng)，維持肺微血管屏障功能，糾正炎癥與凝血失衡，增強(qiáng)細(xì)胞自噬減輕膿毒癥引起的肺損傷?？偨Y(jié)了丹參酮Ⅱ_A防治膿毒癥肺損傷的藥理作用研究進(jìn)展，為膿毒癥肺損傷的臨床治療提供參考。

Sepsis is a systemic inflammatory response caused by infection, which often leads to multiple organ failure. Among them, lung injury is an early and serious complication, and clinical treatment methods are limited. Tanshinone Ⅱ_A is a diterpenoid quinone compound from Salviae Miltiorrhizae Radix et Rhizoma. Tanshinone II_A can alleviate sepsis induced lung injury by reducing inflammatory response, lowering oxidative stress response, maintaining pulmonary microvascular barrier function, correcting inflammation and coagulation imbalance, enhancing cellular autophagy. This article summarizes the pharmacological research progress of tanshinone II_A in preventing and treating sepsis induced lung injury, providing reference for the clinical treatment of sepsis induced lung injury.

R285.5;R974