阿爾茨海默病是最常見的神經(jīng)退行性疾病，而沉默信息調(diào)節(jié)因子1（Sirt1）具有作為阿爾茨海默病治療靶點的潛力。多酚類化合物是植物次生代謝產(chǎn)物，可通過調(diào)節(jié)Sirt1抑制β-淀粉樣蛋白（Aβ）蛋白生成、抑制Tau蛋白磷酸化、抗氧化應激、抑制神經(jīng)炎癥、增強突觸可塑性、增強細胞自噬、抑制神經(jīng)元凋亡，達到改善阿爾茨海默病。綜述了多酚類化合物通過調(diào)節(jié)Sirt1活性改善阿爾茨海默病的分子機制，為開發(fā)基于天然產(chǎn)物的阿爾茨海默病干預策略提供參考。

Alzheimer's disease is the most common neurodegenerative disease, and silent information regulatory factor 1 (Sirt1) has the potential to be a therapeutic target for treatment of Alzheimer's disease. Polyphenolic compounds are the secondary metabolites in plants that can improve Alzheimer's disease by regulating Sirt1 to inhibit the production of β-amyloid (Aβ) protein, suppress Tau protein phosphorylation, resist oxidative stress, suppress neuroinflammation, enhance synaptic plasticity, enhance autophagy, and inhibit neuronal apoptosis. This article reviews the molecular mechanisms of polyphenolic compounds in improving Alzheimer's disease by regulating Sirt1, to provid reference for the development of natural product based intervention strategies for treatment of Alzheimer's disease.

R285.5;R971

陜西省重點研發(fā)計劃項目（2023-YBSF-152）