目的 探討金蓮花口服液聯(lián)合鹽酸米諾環(huán)素軟膏治療慢性牙周炎的臨床療效。方法 將2023年6月—2025年5月在河北醫(yī)科大學(xué)口腔醫(yī)院就診的82例慢性牙周炎患者納入研究，所有患者按隨機(jī)數(shù)字表法分為對照組和治療組，每組41例。對照組將鹽酸米諾環(huán)素軟膏注滿患牙牙周，1次/周。治療組在對照組基礎(chǔ)上口服金蓮花口服液，3次/d，1支/次。兩組患者持續(xù)治療4周。比較兩組的臨床療效、生活質(zhì)量、牙周指標(biāo)、齦溝液炎癥因子。結(jié)果 對照組的總有效率為80.49%，治療組的總有效率為95.12%，組間比較差異顯著（P＜0.05）。兩組治療后的口腔健康影響程度量表（OHIP-49）評分均減?。?i>P＜0.05），且治療后治療組OHIP-49評分低于對照組（P＜0.05）。治療后，兩組的菌斑指數(shù)（PI）、軟垢指數(shù)（DI）、牙石指數(shù)（CI）評分均減?。?i>P＜0.05）；治療組PI、DI、CI評分均小于對照組（P＜0.05）。兩組患者治療后的齦溝液核因子NF-κB受體活化因子配體（RANKL）/骨保護(hù)素（OPG）、基質(zhì)金屬蛋白酶-8（MMP-8）、高遷移率族蛋白B1（HMGB1）水平明顯降低（P＜0.05），治療組治療后齦溝液RANKL/OPG、MMP-8、HMGB1水平低于對照組（P＜0.05）。結(jié)論 慢性牙周炎患者經(jīng)金蓮花口服液聯(lián)合鹽酸米諾環(huán)素軟膏治療，可提高患者的臨床療效、生活質(zhì)量，改善牙周情況，其機(jī)制與減輕炎癥反應(yīng)有關(guān)。

Objective To explore the efficacy of Jinlianhua Oral Liquid combined with Minocycline Hydrochloride Ointments in treatment of chronic periodontitis. Methods 82 Patients with chronic periodontitis who visited Hospital of Stomatology Hebei Medical University from June 2023 to May 2025 were included in the study. All patients were divided into control group and treatment group using a random number table method, with 41 patients in each group. The control group filled the affected teeth with Minocycline Hydrochloride Ointments once weekly. The treatment group took Jinlianhua oral liquid orally on the basis of the control group, 3 times daily, 1 bottle per time. Two groups of patients were treated continuously for 4 weeks. The clinical efficacy, quality of life, periodontal indicators, and gingival crevicular fluid inflammatory factors were compared between two groups. Results The total effective rate of the control group was 80.49%, while the total effective rate of the treatment group was 95.12%, and the difference between two groups was significant (P < 0.05). The Oral Health Impact Scale (OHIP-49) scores were decreased in two groups after treatment (P < 0.05), and the OHIP-49 score in the treatment group was lower than that in the control group after treatment (P < 0.05). After treatment, the plaque index (PI), plaque index (DI), and calculus index (CI) scores of two groups were significantly reduced (P < 0.05), and the PI, DI, and CI scores of the treatment group were all lower than those of the control group (P < 0.05). After treatment, the levels of nuclear factor NF-κB receptor activator ligand (RANKL)/osteoprotegerin (OPG), matrix metalloproteinase-8 (MMP-8), and high mobility group protein B1 (HMGB1) in gingival crevicular fluid of two groups of patients were significantly reduced (P < 0.05), and the levels of RANKL/OPG, MMP-8, and HMGB1 in gingival crevicular fluid of the treatment group were lower than those of the control group after treatment (P < 0.05). Conclusion The combination of Jinlianhua Oral Liquid and Minocycline Hydrochloride Ointments can improve clinical efficacy in treatment of chronic periodontitis, improve quality of life, and periodontal condition, and its mechanism is related to reducing inflammatory response

R988.2

河北省重點(diǎn)研發(fā)計(jì)劃自籌項(xiàng)目（172777138）