目的 探討康復(fù)新液聯(lián)合艾普拉唑鈉治療消化性潰瘍出血的臨床療效。方法 2021年3月—2024年3月選取資陽市精神病醫(yī)院和資陽市中醫(yī)醫(yī)院收治的92例消化性潰瘍出血患者參與研究，以隨機(jī)數(shù)字表法分為對照組和治療組，各46例。對照組靜脈滴注注射用艾普拉唑鈉，1次/d，首次劑量20 mg，后續(xù)劑量10 mg，以10 mg∶100 mL的比例與生理鹽水混合使用。治療組在對照組治療基礎(chǔ)上口服康復(fù)新液，10 mL/次，3次/d。兩組患者療程7 d。評估兩組臨床療效，比較兩組禁食時間和癥狀緩解時間。比較治療前后兩組Rockall、簡式抑郁–焦慮–壓力量表（DASS-21）和睡眠狀況自評量表（SRSS）評分，及紅細(xì)胞計數(shù)（RBC）、血紅蛋白（Hb）、血細(xì)胞比容（HCT）、單核細(xì)胞趨化蛋白1（MCP-1）和白細(xì)胞介素-17（IL-17）水平。結(jié)果 治療后，治療組總有效率明顯高于對照組（95.65% vs 82.61%，P＜0.05）。治療后，治療組患者禁食時間和各項癥狀緩解時間均明顯短于對照組（P＜0.05）。治療后，兩組Rockall、DASS-21和SRSS評分均明顯低于同組治療前（P＜0.05），且治療組患者明顯低于對照組（P＜0.05）。治療后，兩組RBC、Hb、HCT均高于組內(nèi)治療前，而MCP-1、IL-17水平均低于同組治療前（P＜0.05），且治療組RBC、Hb、HCT和血清MCP-1、IL-17水平改善明顯優(yōu)于對照組（P＜0.05）。結(jié)論 康復(fù)新液聯(lián)合艾普拉唑鈉進(jìn)行消化性潰瘍出血的臨床治療，可顯著減輕患者臨床癥狀及體內(nèi)炎癥反應(yīng)，消化性潰瘍出血，促進(jìn)胃腸道黏膜修復(fù)及出血控制，并能有效改善患者的不良情緒、睡眠及貧血狀況。

Objective To explore the clinical efficacy of Kangfuxin Liquid combined with ilaprazole sodium in treatment of peptic ulcer bleeding. Methods Patients (92 cases) with peptic ulcer bleeding in Ziyang Traditional Chinese Medicine Hospital from March 2021 to March 2024 were randomly divided into control and treatment group, and each group had 46 cases. Patients in the control group were iv administered with Ilaprazole Sodium for injection, the first dose was 20 mg and subsequent dose was 10 mg, mixed with 0.9% sodium chloride solution at a ratio of 10 mg∶100 mL, once daily. Patients in the treatment group were po administered with Kangfuxin Liquid on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluations were evaluated, and the fasting time and symptom relief time, the scores of Rockall, DASS-21 and SRSS, the levels of BC, Hb, HCT, MCP-1 and IL-17 in two groups before and after treatment were compared. Results After treatment, the total effective rate in the treatment group was significantly higher than that in the control group (95.65% vs 82.61%, P < 0.05). After treatment, the fasting time and the relief time of various symptoms in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, the scores of Rockall, DASS-21 and SRSS in two groups were significantly lower than those in the same group before treatment (P < 0.05), and patients in the treatment group were significantly lower than those in the control group (P < 0.05). After treatment, RBC, Hb, and HCT in two groups were higher than before treatment, while MCP-1 and IL-17 levels were lower than before treatment in the same group (P < 0.05). After treatment, the RBC, Hb, HCT and serum MCP-1 and IL-17 levels in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion The treatment of peptic ulcer bleeding with Kangfuxin Liquid combined with ilaprazole sodium can effectively reduce gastrointestinal inflammation and clinical symptoms, promote gastrointestinal mucosal repair and bleeding control, and effectively improve patients' negative emotions, sleep, and anemia.

R975

資陽市科學(xué)技術(shù)局計劃項目（KY2023086）