脂肪肝與酒精、肥胖、高血壓、糖尿病、代謝綜合征、心血管疾病密切相關(guān)，近年來發(fā)病率呈上升趨勢，且年輕化加重。丹皮酚是由牡丹皮提取的酚類化合物，可通過調(diào)脂作用、抑制脂滴形成和積累、減輕炎癥反應(yīng)、減輕氧化應(yīng)激反應(yīng)、抑制肝纖維化、調(diào)節(jié)腸道菌群發(fā)揮抗脂肪肝的作用?？偨Y(jié)了丹皮酚治療脂肪肝的藥理作用研究進(jìn)展，為丹皮酚治療脂肪肝的臨床應(yīng)用提供參考。

Fatty liver is closely related to alcohol, obesity, hypertension, diabetes, metabolic syndrome. In recent years, the incidence rate of fatty liver is on the rise and getting younger. Paeonol is a phenolic compound extracted from Moutan Cortex. Paeonol can exert anti-fatty liver effects by regulating lipid levels, inhibiting lipid droplet formation and accumulation, reducing inflammatory reactions, alleviating oxidative stress reactions, inhibiting liver fibrosis, and regulating intestinal flora. This article summarizes the research progress on the pharmacological effects of paeonol in treatment of fatty liver, providing reference for the clinical application of paeonol in treatment of fatty liver.

R977

保定市科技計劃項目（2041ZF115）