胃癌是常見的消化系統(tǒng)腫瘤，發(fā)病率和死亡率均位居惡性腫瘤前列，以化療、放療、靶向治療和免疫治療等為主。他汀類藥物是3-羥基-3-戊二酰輔酶A還原酶的抑制劑，通過抑制癌細(xì)胞增殖、誘導(dǎo)癌細(xì)胞凋亡、抑制胃癌細(xì)胞侵襲和轉(zhuǎn)移、抑制幽門螺桿菌中的細(xì)胞毒素相關(guān)基因A的易位/磷酸化、抑制YAP和β-catenin信號(hào)傳導(dǎo)阻礙胃癌的發(fā)生、發(fā)展，發(fā)揮抗腫瘤作用。他汀類藥物在臨床治療中可增強(qiáng)化療、放療、靶向治療和免疫治療的療效，降低胃癌的發(fā)生率和病死率。對(duì)他汀類藥物治療胃癌的作用機(jī)制和臨床應(yīng)用進(jìn)行總結(jié)，以指導(dǎo)臨床實(shí)踐。

Gastric cancer is a common tumor of the digestive system, and its incidence rate and mortality rate are among the top of malignant tumors, mainly including chemotherapy, radiotherapy, targeted therapy and immunotherapy. Statins are 3-hydroxy-3-glutaryl-coenzyme reductase inhibitors, and exert anti-tumor effects by inhibiting cancer cell proliferation, inducing cancer cell apoptosis, suppressing gastric cancer cell invasion and metastasis, inhibiting the translocation/phosphorylation of cytotoxin related gene A in Helicobacter pylori, inhibiting YAP and β-catenin signaling, and hindering the occurrence and development of gastric cancer. Statins can enhance the efficacy of chemotherapy, radiotherapy, targeted therapy, and immunotherapy in clinical treatment, and reduce the incidence and mortality of gastric cancer. This article summarizes the mechanism and clinical application of statins in treatment of gastric cancer, in order to guide clinical practice.

R979.1

甘肅省自然科學(xué)基金項(xiàng)目（23JRRA1288）