糖尿病是臨床最常見的代謝性疾病，是心血管疾病的獨立危險因素。臨床防治糖尿病心肌損傷的藥物作用機制較單一。小檗堿可通過降低血糖、調(diào)節(jié)心肌脂質(zhì)代謝、改善心肌細(xì)胞能量代謝、減輕炎癥反應(yīng)、增強抗氧化作用、降低心肌細(xì)胞凋亡、減輕心律失常、延緩心肌重塑、促進新血管形成多途徑、多靶點降低高糖引起的心肌損傷，發(fā)揮心肌保護作用。綜述了小檗堿對糖尿病心肌損傷的保護作用，為小檗堿的臨床應(yīng)用提供理論依據(jù)。

Diabetes is the most common metabolic disease in clinic and an independent risk factor for cardiovascular disease. The mechanism of drugs for treating myocardial injury in diabetes is relatively simple. Berberine can reduce myocardial injury caused by high glucose through multiple pathways and multiple targets by lowering blood sugar, regulating myocardial lipid metabolism, improving myocardial cell energy metabolism, alleviating inflammatory response, enhancing antioxidant effect, reducing myocardial cell apoptosis, alleviating arrhythmia, delaying myocardial remodeling, and promoting neovascularization. This article reviews the protective effect of berberine on diabetic myocardial injury, and provides theoretical basis for clinical application of berberine.

R286.2

北京市醫(yī)院管理中心青年人才培養(yǎng)“青苗”計劃（QML20232224）