高尿酸血癥是一種慢性代謝性疾病，現(xiàn)有的臨床治療藥物主要以控制尿酸水平為目標(biāo)。植物雌激素是一類存在于植物中的具有弱雌激素作用的雜環(huán)多酚類化合物，可以通過抑制黃嘌呤氧化酶、促進(jìn)尿酸排泄轉(zhuǎn)運(yùn)蛋白的表達(dá)和活性、抑制尿酸重吸收蛋白表達(dá)、改善腸道菌群多樣性防治高尿酸血癥，同時(shí)防治高尿酸血癥并發(fā)癥高血壓、動脈粥樣硬化和代謝相關(guān)脂肪性肝病。總結(jié)了植物雌激素防治高尿酸血癥及其并發(fā)癥的研究進(jìn)展，為植物雌激素防治高尿酸血癥的臨床應(yīng)用提供參考。

Hyperuricemia is a chronic metabolic disease, and existing clinical treatment drugs mainly aim to control uric acid levels. Phytoestrogens are a class of heterocyclic polyphenolic compounds that exist in plants and have weak estrogenic effects. Phytoestrogens can prevent and treat hyperuricemia by inhibiting xanthine oxidase, promoting the expression and activity of uric acid excretion transporter, inhibiting the expression of uric acid reabsorption protein, improving the diversity of intestinal flora, and preventing and treating hyperuricemia complications such as hypertension, arterial atherosclerosis and metabolism related fatty liver disease. This article summarizes the research progress on phytoestrogens in prevention and treatment of hyperuricemia and its complications, providing reference for the clinical application of phytoestrogens in prevention and treatment of hyperuricemia.

R282.71

天津市中醫(yī)藥重點(diǎn)領(lǐng)域科研項(xiàng)目（2024009）；新疆維吾爾自治區(qū)科技計(jì)劃項(xiàng)目（2022LQ04007）