目的 探討玉屏風(fēng)顆粒聯(lián)合鹽酸多西環(huán)素片治療兒童支原體肺炎的臨床療效。方法 選取2023年3月—2024年12月川北醫(yī)學(xué)院附屬三臺(tái)醫(yī)院收治的82例支原體肺炎患兒，按隨機(jī)數(shù)字表法將82例患兒分為對(duì)照組和治療組，每組41例。對(duì)照組口服鹽酸多西環(huán)素片，每12小時(shí)服藥1次，每次劑量2.2 mg/kg。治療組患兒在對(duì)照組基礎(chǔ)上溫水沖服玉屏風(fēng)顆粒，1袋/次，3次/d。兩組持續(xù)治療7 d。比較兩組的臨床效果、癥狀消失時(shí)間和血清指標(biāo)。結(jié)果 對(duì)照組的總有效率為80.49%，治療組的總有效率為95.12%，組間比較差異顯著（P＜0.05）。治療組患兒發(fā)熱、咳嗽、肺啰音消失時(shí)間均短于對(duì)照組（P＜0.05）。治療后，兩組的血清血清淀粉樣蛋白A/C反應(yīng)蛋白（SAA/CRP）、半胱氨酰白三烯（CysLTs）、免疫球蛋白M（IgM）均降低（P＜0.05）；治療組的血清SAA/CRP、CysLTs、IgM均低于對(duì)照組（P＜0.05）。結(jié)論 玉屏風(fēng)顆粒聯(lián)合鹽酸多西環(huán)素片可提高兒童支原體肺炎的臨床療效，減輕臨床癥狀和炎癥反應(yīng)。

Objective To explore the clinical efficacy of Yupingfeng Granules combined with Doxycycline Hydrochloride Tablets in treatment of mycoplasma pneumonia in children. Methods 82 Children with mycoplasma pneumonia admitted to Santai Hospital Affiliated to North Sichuan Medical College from March 2023 to December 2024 were divided into control group and treatment group according to random number table method, with 41 cases in each group. Children in the control group took Doxycycline Hydrochloride Tablets orally, once every 12 hours, with a dose of 2.2 mg/kg each time. On the basis of the control group, the treatment group took Yupingfeng Granules orally in warm water, 3 times daily, 1 bag/time. Two groups received continuous treatment for 7 days. The clinical efficacy, symptom disappearance time, and serum indicators were compared between two groups. Results The total effective rate of the control group was 80.49%, and the total effective rate of the treatment group was 95.12%, with significant differences between two groups (P < 0.05). The disappearance times of fever, cough, and lung rales in the treatment group was shorter than those in the control group (P < 0.05). After treatment, the serum levels of SAA/CRP, CysLTs, and IgM in two groups were significantly decreased (P < 0.05), and the serum levels of SAA/CRP, CysLTs, and IgM in the treatment group were lower than those in the control group (P < 0.05). Conclusion The combination of Yupingfeng Granules and Doxycycline Hydrochloride Tablets can improve the clinical efficacy of mycoplasma pneumonia in children, alleviate clinical symptoms and inflammatory reactions.

R974

四川養(yǎng)老與老年健康協(xié)同創(chuàng)新中心聯(lián)合基金項(xiàng)目（YLKYYB2222）