目的 研究杏貝止咳顆粒聯(lián)合丙卡特羅在小兒急性支氣管炎中的臨床應(yīng)用效果。方法 本研究納入2023年3月—2024年9月重慶市第七人民醫(yī)院收治的112例急性支氣管炎患兒，所有病例皆滿足納入標準并接受了規(guī)范化的診療，通過隨機數(shù)字表法將病例分為對照組和治療組，每組各納入了56例患兒。對照組采用鹽酸丙卡特羅口服溶液干預(yù)，年齡≤6歲0.25 mL/kg，1日2次，6歲以上患兒5 mL/次，1日2次。治療組在對照組干預(yù)方案基礎(chǔ)上加用杏貝止咳顆粒，實施年齡分層給藥策略，l歲≤年齡＜3歲1/3袋/次，3歲≤年齡＜6歲1/2袋/次，年齡≥6歲1袋/次，1日3次，均以溫開水沖服。兩組均維持7 d標準化療程。觀察兩組患者的臨床療效和癥狀消失時間，比較兩組治療前后萊徹斯特咳嗽問卷評分、咳嗽癥狀積分、超敏C反應(yīng)蛋白（hs-CRP）、降鈣素原（PCT）和白細胞（WBC）水平的變化情況。結(jié)果 治療后，治療組急性支氣管炎患兒的總有效率（96.43%）顯著高于對照組（85.71%），組間比較差異具有統(tǒng)計學(xué)意義（P＜0.05）。癥狀改善方面，治療組咳嗽、咳痰消失時間均短于對照組（均P＜0.05）。兩組患兒治療后萊徹斯特咳嗽問卷評分顯著升高，咳嗽癥狀積分則顯著降低，其中治療組的改善幅度顯著優(yōu)于對照組（P＜0.05）。血清學(xué)檢測結(jié)果表明，兩組血清hs-CRP、PCT和WBC水平均顯著下降（P＜0.05），且治療組下降程度均優(yōu)于對照組（P＜0.05）。結(jié)論 杏貝止咳顆粒聯(lián)合丙卡特羅治療小兒急性支氣管炎具有明確臨床優(yōu)勢，能夠有效縮短核心癥狀持續(xù)時間并改善患兒生活質(zhì)量，同時促進血清學(xué)相關(guān)指標復(fù)常，為構(gòu)建兒童支氣管炎中西醫(yī)結(jié)合階梯治療方案提供了關(guān)鍵循證依據(jù)。

Objective To investigate the clinical application effects of Xingbei Zhike Granules combined with procaterol in children with acute bronchitis. Methods This study enrolled 112 children with acute bronchitis who were admitted to Chongqing Seventh People’s Hospital from March 2023 to September 2024. All cases met the inclusion criteria and received standardized diagnosis and treatment. Using a random number table method, the patients were divided into a treatment group and a control group, with 56 cases in each group. Children in control group received oral treatment with Procaterol Hydrochloride Oral Solution, 0.25 mL/kg for children ≤ 6 years old, twice daily, and 5 mL/time for children over 6 years old, twice daily. Children in treatment group were given oral treatment with Xingbei Zhike Granules on the basis of the control group, l year ≤ children < 3 years, 1/3 bags/time, 3 year ≤ children < 6 years, 1/2 bags/time, and 1 bag/time for children ≥ 6 years old, 3 times daily, with boiling water. Both groups were treated for 7 d. The clinical efficacy and symptom resolution time of two groups were observed, and the changes of leicester cough questionnaire score, cough symptom score, hs-CRP, PCT, and WBC levels before and after treatment were compared between two groups. Results After intervention, the clinical total effective rate of the treatment group for children with acute bronchitis (96.43%) was significantly higher than that of the control group (85.71%), and the difference between the groups was statistically significant (P < 0.05). In terms of symptom improvement, the disappearance time of cough and sputum in the treatment group was shorter than that in the control group (P < 0.05). After treatment, the Leicester cough questionnaire scores of the two groups of children significantly increased, while the cough symptom scores significantly decreased. The improvement in the treatment group was significantly better than that in the control group (P < 0.05). Serological test results showed that serum hs-CRP, PCT, and WBC levels in both groups were significantly decreased (P < 0.05), and the reduction degree in the treatment group was better than that in the control group (P < 0.05). Conclusion Xingbei Zhike Granules combined with procaterol has clear clinical advantages in the treatment of acute bronchitis in children, and can effectively shorten the duration of core symptoms and improve the life quality of children, while promoting the normalization of serological related indicators. This provides key evidence-based support for the construction of a combination of traditional Chinese and Western medicine tiered treatment plan for pediatric bronchitis.

R974

重慶市科衛(wèi)聯(lián)合青年項目（MSX0421）