目的 探討芪血顆粒聯(lián)合復(fù)方硫酸亞鐵顆粒治療妊娠期缺鐵性貧血的臨床療效。方法 選取2022年3月—2024年10月在邢臺(tái)市中心醫(yī)院就診的妊娠期貧血患者共90例，按隨機(jī)數(shù)字表法分為對(duì)照組和治療組，每組45例。對(duì)照組開(kāi)水沖服復(fù)方硫酸亞鐵顆粒，1袋/次，1次/d。治療組在對(duì)照組的基礎(chǔ)上開(kāi)水沖服芪血顆粒，1袋/次，3次/d。兩組持續(xù)治療2個(gè)月。比較兩組的臨床療效、癥狀消失時(shí)間、紅細(xì)胞指標(biāo)、鐵代謝指標(biāo)。結(jié)果 對(duì)照組的總有效率為82.22%，明顯低于治療組的總有效率95.56%，組間差異顯著（P＜0.05）。治療組患者的虛弱、頭暈頭痛、手腳冰涼、呼吸急促消失時(shí)間均短于對(duì)照組（P＜0.05）。治療后，兩組的紅細(xì)胞計(jì)數(shù)、紅細(xì)胞平均血紅蛋白、平均紅細(xì)胞體積明顯升高（P＜0.05），且治療組的紅細(xì)胞計(jì)數(shù)、紅細(xì)胞平均血紅蛋白、平均紅細(xì)胞體積明顯高于對(duì)照組（P＜0.05）。治療后，兩組的鐵蛋白升高，可溶性轉(zhuǎn)鐵蛋白受體、不飽和鐵結(jié)合力降低（P＜0.05）；治療組患者的鐵蛋白高于對(duì)照組，可溶性轉(zhuǎn)鐵蛋白受體、不飽和鐵結(jié)合力低于對(duì)照組（P＜0.05）。結(jié)論 芪血顆粒聯(lián)合復(fù)方硫酸亞鐵顆粒可提高妊娠期貧血的臨床療效，促進(jìn)癥狀改善，改善紅細(xì)胞參數(shù)和鐵代謝。

Objective To explore the clinical efficacy of Qixue Granules combined with Compound Ferrous Sulfate Granules in treatment of anemia in pregnancy. Methods 90 Patients with anemia in pregnancy who visited Xingtai Central Hospital from March 2022 to October 2024 were selected and were divided into control group and treatment group using a random number table method, with 45 cases in each group. Patients in the control group took Compound Ferrous Sulfate Granules with boiled water, 1 bag/time, once daily. On the basis of the control group, patients in the treatment group took Qixue Granules with boiled water, 1 bag/time, 3 times daily. Two groups received 2 months of continuous treatment. The clinical efficacy, symptom disappearance time, red blood cell indicators, and iron metabolism indicators were compared between two groups. Results The total effective rate of patients in the control group was 82.22%, that in the treatment group was 95.56%, and the difference between two groups was significant (P < 0.05). The disappearance time of weakness, dizziness, headache, cold hands and feet, and shortness of breath in the treatment group was shorter than that in the control group (P < 0.05). The red blood cell count, average red blood cell hemoglobin, and average red blood cell volume of the two groups were significantly increased after treatment (P < 0.05), and red blood cell count, average red blood cell hemoglobin, and average red blood cell volume in the treatment group were higher than those in the control group (P < 0.05). After treatment, ferritin levels in both groups were increased, but the soluble transferrin receptor and unsaturated iron binding capacity were decreased (P < 0.05). The ferritin levels in the treatment group were higher than those in the control group, but the soluble transferrin receptor and unsaturated iron binding capacity were lower than those in the control group (P < 0.05). Conclusion Qixue Granules combined with Compound Ferrous Sulfate Granules can improve the efficacy of pregnancy anemia, promote symptom improvement efficiency, improve red blood cell parameters and iron metabolism.

R984

邢臺(tái)市重點(diǎn)研發(fā)計(jì)劃自籌項(xiàng)目（2023ZC065）