目的 探討連花清瘟顆粒聯(lián)合乙酰半胱氨酸在小兒毛細(xì)支氣管炎治療中的臨床療效。方法 回顧性分析2022年6月—2024年6月在海安市中醫(yī)院診治的毛細(xì)支氣管炎患兒92例，根據(jù)不同的治療方案分為對(duì)照組和治療組，每組各46例。對(duì)照組患兒霧化吸入吸入用乙酰半胱氨酸溶液，每次1.5 mL用無菌生理鹽水稀釋至5 mL，2次/d；治療組在對(duì)照組基礎(chǔ)上口服連花清瘟顆粒，1.5 g/次，3次/d。兩組患兒均給予5 d治療。觀察兩組患兒臨床療效，比較治療前后兩組患兒癥狀消退時(shí)間和住院時(shí)間，血清白三烯C4（LTC4）、淀粉樣蛋白A（SAA）和肺表面活性物質(zhì)相關(guān)蛋白D（SP-D）水平。結(jié)果 治療后，對(duì)照組和治療組患兒總有效率分別為82.61%和95.65%，兩組比較差異具有統(tǒng)計(jì)學(xué)差異（P＜0.05）。治療后，治療組患兒退熱、咳嗽消失、喘鳴音消失時(shí)間及住院時(shí)長(zhǎng)均顯著短于對(duì)照組（P＜0.05）。經(jīng)過治療，兩組毛細(xì)支氣管炎患兒血清LTC4、SAA和SP-D水平均顯著下降（P＜0.05），且治療組下降程度均高于對(duì)照組（P＜0.05）。結(jié)論 連花清瘟顆粒聯(lián)合乙酰半胱氨酸治療小兒毛細(xì)支氣管炎療效顯著，不僅能夠有效縮短患兒癥狀消退時(shí)間和住院時(shí)間，而且還能夠促進(jìn)血清學(xué)相關(guān)指標(biāo)的修復(fù)。

Objective Exploring the clinical efficacy of Lianhua Qingwen Granules combined with acetylcysteine in treatment of pediatric bronchiolitis. Methods The clinical data of children (92 cases) with bronchiolitis in Hai'an Traditional Chinese Medicine Hospital from June 2022 to June 2024 were analyzed retrospectively. They were divided into control and treatment group based on different treatments, and each group had 46 cases. Children in the control group were aerosol inhalation administered with Acetylcysteine Solution for inhalation, 1.5 mL was diluted to 5 mL each time with sterile physiological saline, twice daily. Children in the treatment group were po administered with Lianhua Qingwen Granules on the basis of the control group, 1.5 g/time, three times daily. Children in two groups were treated for 5 d. After treatment, the clinical evaluations were evaluated, the symptom resolution time and hospitalization time, and serum LTC4, SAA, and SP-D levels in two groups before and after treatment were compared. Results After treatment, the total clinical effective rates in the control group and the treatment group were 82.61% and 95.65%, respectively, with a statistical difference between two groups (P < 0.05). After treatment, The time of fever, cough, wheezing sound and hospital stay in the treatment group were significantly shorter than those in the control group (P < 0.05). After treatment, the serum LTC4, SAA and SP-D levels were significantly decreased in two groups (P < 0.05), and the degree of decline in the treatment group was significantly higher than that in the control group (P < 0.05). Conclusion Lianhua Qingwen Granules combined with acetylcysteine have significant curative effects in the treatment of pediatric bronchiolitis. It can not only effectively shorten the symptom resolution time and hospital stay in children, but also promote the repair of serology-related indicators.

R974

南通市中醫(yī)醫(yī)療聯(lián)盟課題（TZYK202016）