子癇前期是一種嚴(yán)重妊娠并發(fā)癥，臨床治療以解痙藥物、抗凝藥物、降壓藥物為主。葛根素是由葛根中提取的異黃酮類成分，具有一系列生物活性，可通過(guò)改善血管內(nèi)皮功能、減輕氧化應(yīng)激反應(yīng)、減輕炎癥反應(yīng)、抑制滋養(yǎng)層細(xì)胞過(guò)度凋亡、增強(qiáng)抗缺氧能力、改善滋養(yǎng)層細(xì)胞運(yùn)動(dòng)功能、降低胰島素抵抗發(fā)揮治療子癇前期的作用。綜述了葛根素防治子癇前期的作用機(jī)制研究進(jìn)展，為子癇前期的藥物治療提供參考。

Preeclampsia is a serious complication of pregnancy, and clinical treatment mainly includes antispasmodic drugs, anticoagulants, and antihypertensive drugs. Puerarin is a flavonoid component extracted from Puerariae Lobatae Radix, with series of biological activities, and can improve endothelial function of blood vessels, alleviate oxidative stress response, reduce inflammatory response, inhibit excessive apoptosis of trophoblast cells, enhance anti-hypoxia ability, improve trophoblast cell motility, reduce insulin resistance, and exert therapeutic effects on preeclampsia through multiple pathways. This article reviews the research progress of mechanism of puerarin in prevention and treatment of preeclampsia, and provides reference for the drug treatment of preeclampsia.

R972

重慶市大足區(qū)科技發(fā)展項(xiàng)目（DZKJ2024JSYJ-KWXM1062）