[關鍵詞]
[摘要]
目的 探討保和丸聯合地衣芽孢桿菌活菌顆粒治療功能性消化不良的臨床療效。方法 將2023年6月—2024年5月在天津醫(yī)科大學附屬寶坻醫(yī)院就診的功能性消化不良患者共94例作為研究對象,按隨機數字表法將所有患者分為對照組和治療組,每組47例。對照組口服地衣芽孢桿菌活菌顆粒,1袋/次,3次/d。治療組在對照組的基礎上口服保和丸,8丸/次,3次/d。兩組在完成4周的治療后分析療效。比較兩組患者的治療效果、癥狀程度、胃腸動力學和血清指標。結果 治療后,對照組和治療組的總有效率分別為78.72%、93.62%,組間差異顯著(P<0.05)。治療后,兩組餐后飽脹不適、中上腹痛、中上腹燒灼感、早飽感的發(fā)作頻率、嚴重程度評分降低(P<0.05),且治療組餐后飽脹不適、中上腹痛、中上腹燒灼感、早飽感的發(fā)作頻率、嚴重程度評分較對照組更低(P<0.05)。治療后,兩組患者的胃排空率、胃蠕動次數和收縮次數均升高(P<0.05);治療組的胃排空率、胃蠕動次數和收縮次數高于對照組(P<0.05)。治療后,兩組血清胃促生長素、瘦素水平顯著升高,血清血管活性腸肽水平降低(P<0.05);治療組的血清胃促生長素、瘦素水平高于對照組,血清血管活性腸肽水平低于對照組(P<0.05)。結論 保和丸聯合地衣芽孢桿菌活菌顆??商岣吖δ苄韵涣嫉寞熜ВM一步減輕臨床癥狀,促進胃排空,調節(jié)胃腸激素。
[Key word]
[Abstract]
Objective To explore the clinical efficacy of Baohe Pills combined with Bacillus licheniformis Granules, Live in treatment of functional dyspepsia.Methods 94 Patients with functional dyspepsia from Baodi Hospital Affiliated to Tianjin Medical University were divided into the control and treatment groups with random number table method, 47 cases/group. Patients in the control group took Bacillus licheniformis Granules, Live, 1 bag/time, 3 times daily. Patients in the treatment group took Baohe Pills, 8 pills/time, 3 times daily on the basis of the control group. The efficacy of the 2 groups were analyzed after completing 4 weeks of treatment. The treatment efficacy, symptom severity, gastrointestinal dynamics, and serum indicators were compared between two groups. ResultsThe total effective rate was 78.72% in the control group and 93.62% in the treatment group, with significant difference between groups (P<0.05). After treatment, frequency and severity of postprandial fullness discomfort, mid-upper abdominal pain, mid-upper abdominal burning sensation, and early satiety in the two groups were decreased (P < 0.05), and these indexes the treatment group was significantly lower than those in the control group (P < 0.05). After treatment, the gastric emptying rate, the number of gastric peristalsis and the number of contractions in the two groups were all increased (P < 0.05), and the gastric emptying rate, the number of gastric peristalsis and the number of contractions in the treatment group were higher than those in the control group (P < 0.05). After treatment, gastrophin and leptin in the two groups were increased, but vasoactive intestinal peptide was decreased (P < 0.05), and gastrophin and leptin in the treatment group were higher than those in the control group, but vasoactive intestinal peptide was lower than before treatment (P < 0.05). ConclusionBaohe Pills combined with Bacillus licheniformis Granules, Live can improve the efficacy of functional dyspepsia, further reduce clinical symptoms, promote gastric emptying, and regulate gastrointestinal hormones.
[中圖分類號]
R975
[基金項目]