代謝綜合征是胰島素抵抗、肥胖等多種已知的心血管危險因素同時在個體內存在的狀態(tài)，其病情復雜，易誘發(fā)多種靶器官損害。胡椒堿屬于桂皮酰胺類生物堿，具有較強的生物活性，可以通過減輕胰島素抵抗、抗肥胖、抗高血脂、減輕代謝相關脂肪性肝病和抗高尿酸血癥顯著改善代謝綜合征。對胡椒堿改善代謝綜合征的藥理作用及其機制的相關研究進行歸納和綜述，以期為胡椒堿的深入研究和開發(fā)利用提供參考。

Metabolic syndrome is a complex condition characterized by the simultaneous occurrence of multiple known cardiovascular risk factors such as insulin resistance and obesity, which can easily lead to damage to multiple target organs. Piperine, a cinnamamide alkaloid with strong biological activity, significantly improves metabolic syndrome by alleviating insulin resistance, anti-obesity, antihyperlipidemia, reducing metabolic-associated fatty liver disease, and anti-hyperuricemia. This review summarizes the pharmacological effects and mechanisms of piperine in improving metabolic syndrome, aiming to provide a reference for its further research and practical application.

R285.5

遼寧省博士科研啟動基金計劃項目(2023-BS-093); 遼寧省大學生創(chuàng)新創(chuàng)業(yè)訓練計劃項目(202410159020)