糖尿病腎病是2型糖尿病的主要并發(fā)癥之一，是造成終末期腎病和腎功能衰竭患者死亡的主要原因。虎杖苷是從虎杖中提取的活性成分，可通過減輕腎組織炎性損傷、降低氧化應(yīng)激反應(yīng)、延緩腎組織纖維化、阻止腎組織細胞凋亡、降低血糖發(fā)揮防治糖尿病腎病的作用。總結(jié)了虎杖苷用于糖尿病腎病的研究進展，分析了其作用機制，為虎杖苷治療糖尿病腎病的臨床研究提供依據(jù)。

Diabetes nephropathy is one of the major complications of type 2 diabetes, and the main cause of death in patients with end-stage renal disease and renal failure. Polydatin is an active ingredient extracted from Polygoni Cuspidati Rhizoma, which can play a role in preventing and treating diabetes nephropathy by reducing inflammatory damage of renal tissue, reducing oxidative stress response, delaying renal tissue fibrosis, preventing renal tissue cells apoptosis, and reducing blood sugar. This article summarized the research progress of polydatin in treatment of diabetes nephropathy, analyzed its mechanism of action, and provided a basis for the clinical study of polydatin in treatment of diabetes nephropathy.

R285

北京慢性病防治與健康教育科研項目（BJMB0012022028001）