目的 探討腫痛安膠囊聯(lián)合更昔洛韋片治療兒童皰疹性口腔炎的臨床療效。方法 選取2021年9月—2024年8月天津市泰達醫(yī)院收治的皰疹性口腔炎患兒共計86例，按隨機數(shù)字表法將所有患兒分為對照組和治療組，每組各43例。對照組口服更昔洛韋片，5 mg/kg，每日分3次服用。治療組在對照組基礎上外用腫痛安膠囊，3次/d，每次將1粒膠囊的藥粉敷于患處，至少保持1 h。兩組持續(xù)治療14 d。比較兩組患兒的臨床療效、癥狀消失情況、生活質量、免疫球蛋白。結果 治療組的總有效率為95.35%，對照組的總有效率為81.40%，組間差異明顯（P＜0.05）。治療組退熱時間、止痛時間、皰疹消失時間、潰瘍消失時間均短于對照組（P＜0.05）。治療后，兩組的兒童皮膚病生活質量指數(shù)（CDLQI）評分均降低（P＜0.05），且治療組的CDLQI評分低于對照組著（P＜0.05）。治療后，兩組IgA、IgM、IgE均明顯提高（P＜0.05），治療組患兒的IgA、IgM、IgE比對照組更高（P＜0.05）。結論 腫痛安膠囊聯(lián)合更昔洛韋片可提高皰疹性口腔炎的療效，改善臨床癥狀和免疫球蛋白水平，提高生活質量。

Objective To explore the clinical efficacy of the combination of Tongzhong'an Capsules and Ganciclovir Tablets in treatment of pediatric herpetic stomatitis.Methods 86 Children with herpetic stomatitis admitted to Tianjin Teda Hospital from September 2021 to August 2024 were selected and divided into control group and treatment group according to the random number table method, with 43 cases in each group. The control group patients took Ganciclovir Tablets at a dose of 5 mg/kg, divided into three doses daily. On the basis of the control group, the treatment group was treated with external application of Zhongtong'an Capsules, 3 times daily, apply 1 capsule of powder to the affected area each time, and maintained for at least 1 h. Two groups received continuous treatment for 14 d. The clinical efficacy, symptom disappearance, quality of life, and immunoglobulin levels were compared between two groups. Results The total effective rate of the treatment group (95.35%) was higher than 81.40% of the control group, and the difference between the groups was significant (P < 0.05). The fever reduction time, pain relief time, herpes disappearance time, and ulcer disappearance time of the treatment group were all shorter than those of the control group (P < 0.05). CDLQI scores of both groups was decreased (P < 0.05), and CDLQI scores of the treatment group was lower than those of the control group (P < 0.05). IgA, IgM, and IgE in both groups were increased after treatment (P < 0.05), and these indexes in the treatment group were higher than those of the control group (P < 0.05). Conclusion The combination of Zhongtong'an Capsules and Ganciclovir Tablets can improve the efficacy, improve clinical symptoms and immunoglobulin levels, and enhance quality of life.

R985;R988.2