目的 分析裸花紫珠顆粒與西咪替丁注射液聯(lián)合治療上消化道出血的療效。方法 取皖南醫(yī)學院附屬太和醫(yī)院于2022年6月—2023年6月收治的86例上消化道出血患者，根據(jù)隨機信封法將患者分為對照組和治療組，各43例。對照組緩慢靜脈滴注西咪替丁注射液，取2 mL西咪替丁注射液使用5%葡萄糖注射液250 mL稀釋，每8 h一次；治療組在對照組基礎上口服裸花紫珠顆粒，1袋/次，4次/d。兩組均治療3 d。比較兩組臨床療效、再出血率、臨床癥狀改善時間、凝血功能指標和血常規(guī)指標。結(jié)果 治療組的總有效率顯著高于對照組，再出血率低于對照組（P＜0.05）。治療組止血時間、隱血轉(zhuǎn)陰時間、嘔血消失時間、腹痛緩解時間均短于對照組（P＜0.05）。治療后，兩組活化部分凝血活酶時間（APTT）、凝血酶原時間（PT）、凝血酶時間（TT）、纖維蛋白原（FIB）顯著降低（P＜0.05），且治療組患者APTT、PT、TT、FIB低于對照組（P＜0.05）。治療后，兩組血紅蛋白（Hb）、紅細胞計數(shù)（RBC）、血細胞比容（HCT）水平顯著升高（P＜0.05），且治療組Hb、RBC、HCT高于對照組（P＜0.05）。結(jié)論 裸花紫珠顆粒聯(lián)合西咪替丁注射液治療上消化道出血的臨床療效更佳，在改善凝血功能、提高止血效果、降低再出血率方面具有顯著優(yōu)勢。

Objective To explore the curative effect of Luohuazizhu Granules combined with Cimetidine Injection in treatment of upper gastrointestinal bleeding. Methods 86 Patients with upper gastrointestinal bleeding admitted to Taihe Hospital Affiliated to South Anhui Medical College from June 2022 to June 2023 were selected as the study subjects. Patients were divided into control and treatment groups according to the randomized envelope method, and each group had 43 patients. The control group was given intravenous infusion of Cimetidine Injection, and 2 mL Cimetidine Injection was diluted with 250 mL 5% glucose injection before intravenous infusion, once every 8 h. The treatment group were po administered with Luohuazizhu Granules based on control group, 1 bag/time, 4 times daily. Both groups were treated for 3 d. The clinical efficacy, rebleeding rate, improvement time of clinical symptoms, coagulation function indicators, and blood routine indicators between two groups were compared. Results After treatment, the total effective rate of the treatment group was significantly higher than that of the control group, but the rebleeding rate was lower than that of the control group (P < 0.05). The hemostasis time, occult blood turning negative time, vomiting blood disappearance time, and abdominal pain relief time of the treatment group were shorter than those of the control group (P < 0.05). After treatment, the levels of APTT, PT, TT, and FIB in both groups were significantly decreased (P < 0.05), and these coagulation function indicators in the treatment group was lower than those in the control group (P < 0.05). After treatment, the levels of Hb, RBC, and HCT in both groups were significantly increased (P < 0.05), and blood routine indicators in the treatment group was higher than those in the control group (P < 0.05). Conclusion Luohuazizhu Granules combined with Cimetidine Injection is better in treatment of upper gastrointestinal bleeding, with significant advantages in improving coagulation function, enhancing hemostatic effect, and reducing rebleeding rate.

R975

阜陽市自籌類科技計劃項目（FK202081085）