目的 探討清熱八味膠囊聯(lián)合奧司他韋治療流行性病毒感冒的臨床療效。方法 選取2022年3月—2024年3月上海健康醫(yī)學(xué)院附屬崇明醫(yī)院收治的流行性病毒感冒患者104例，隨機(jī)分為對(duì)照組和治療組，每組52例。對(duì)照組磷酸奧司他韋膠囊，1粒/次，每日2次。在對(duì)照組的基礎(chǔ)上，治療組清熱八味膠囊，3～5粒/次，每日1～2次。兩組用藥5 d觀察療效，比較治療前后兩組患者癥狀好轉(zhuǎn)時(shí)間，及炎性因子白介素-6（IL-6）、超氧化物歧化酶（SOD）、γ干擾素（IFN-γ）、腫瘤壞死因子-α（TNF-α）水平。結(jié)果 治療后，治療組總有效率（96.15%）明顯高于對(duì)照組總有效率（82.69%，P＜0.05）。治療后，治療組患者發(fā)熱、頭痛、鼻塞流涕、全身肌肉酸痛等癥狀好轉(zhuǎn)時(shí)間短于對(duì)照組（P＜0.05）好轉(zhuǎn)時(shí)間較對(duì)照組明顯縮短（P＜0.05）。治療后，兩組IL-6、TNF-α水平顯著降低，而SOD、IFN-γ升高（P＜0.05）；治療后，治療組IL-6、TNF-α水平低于對(duì)照組，SOD、IFN-γ水平均高于對(duì)照組（P＜0.05）。結(jié)論 清熱八味膠囊聯(lián)合奧司他韋治療流行性病毒感冒，能有效緩解感冒癥狀，并可改善細(xì)胞免疫功能，調(diào)控炎性因子含量降低。

Objective To explore the therapeutic effect of Qingre Bawei Capsules combined with oseltamivir in treatment of influenza. Methods Patients (104 cases) with influenza in Chongming Hospital Affiliated to Shanghai University of Medicine & Health Sciences from March 2022 to March 2024 were randomly divided into control (52 cases) and treatment (52 cases) . Patients in were po administered with Phosphate Capsules, 1 grain/time, twice daily. Patients in the were po administered with Qingre Bawei Capsules, 3 — 5 grains/time, 1 — 2 times daily. Patients in two 5 d. After treatment, the clinical evaluations were evaluated, the symptoms improved time, the levels of SOD, IL-6, IFN-γ and TNF-α in before and after compared. Results After treatment, the effective rate (96.15%) was higher (82.69%, P < 0.05). After treatment, the improvement time of fever, headache, nasal congestion and body muscle soreness in the treatment group was shorter than that in the control group (P < 0.05). After treatment, the levels of IL-6 and TNF-α were significantly decreased, but SOD and IFN-γ were increased in two groups (P < 0.05). After treatment, the levels of IL-6 and TNF-α in the treatment group were lower than those in the control group, and the levels of SOD and IFN-γ were higher than those in the control group (P < 0.05). Conclusion Qingre Bawei Capsules combined with oseltamivir in treatment of influenza can effectively alleviate cold symptoms, which can also improve cellular immune function and regulate the reduction of inflammatory factor content.

R974

上?？沙掷m(xù)發(fā)展科技創(chuàng)新行動(dòng)計(jì)劃項(xiàng)目（CKY2020-09）