目的 探討注射用炎琥寧（凍干）聯(lián)合利巴韋林注射液治療病毒性肺炎的效果。方法 選取2022年5月—2023年5月蘇州市第九人民醫(yī)院收治的80例病毒性肺炎患者，以隨機數(shù)字表法分為對照組和治療組，每組各40例。對照組患者靜脈滴注利巴韋林注射液，每次500 mg加于500 mL 5%葡萄糖注射液中，2次/d。治療組在對照組基礎上靜脈滴注注射用炎琥寧（凍干），每次400 mg加于250 mL 5%葡萄糖注射液中，1次/d。兩組連續(xù)治療5 d。比較兩組的臨床療效、臨床癥狀緩解時間、炎癥指標。結果 治療后，治療組的總有效率（97.50%）比對照組的總有效率（80.00%）更高（P＜0.05）；治療后，治療組發(fā)熱、咽痛、咳嗽緩解時間均短于對照組（P＜0.05）；治療后，兩組患者血清白細胞介素-6（IL-6）、腫瘤壞死因子-α（TNF-α）、C反應蛋白（CRP）水平均降低（P＜0.05），治療組患者血清IL-6、TNF-α、CRP水平與對照組相比更低（P＜0.05）。結論 注射用炎琥寧（凍干）聯(lián)合利巴韋林注射液治療病毒性肺炎具有較好療效，能有效地緩解臨床癥狀，減輕機體炎癥反應。

Objective To explore the therapeutic effect of Potassium Sodium Pehydroandroandrographolide Succinate for injection (lyophilized) combined with Ribavirin Injection in treatment of viral pneumonia Methods 80 Patients with viral pneumonia admitted to Suzhou Ninth People's Hospital from May 2022 to May 2023 were divided into a control group (n = 40 cases) and a treatment group (n = 40 cases ) using a random number table method. The control group received intravenous infusion of Ribavirin Injection, with each dose of 500 mg added to 500 mL 5% glucose injection, twice daily. On the basis of control group, the treatment group received Potassium Sodium Pehydroandroandrographolide Succinate for injection (lyophilized), with each dose of 400 mg added to 250 mL 5% glucose injection once daily. Both groups were treated for 5 d. The clinical efficacy, symptom relief times, and inflammatory index levels between the two groups were compared. ResultsAfter treatment, the total effective rate of patients in the treatment group (97.50%) was higher than 80.00% in the control group (P< 0.05). After treatment, the improvement time of fever, sore throat, and cough in the treatment group was shorter than those of the control group (P< 0.05). After treatment, the levels of serum IL-6, TNF-α, and CRP in the two groups were lower than those before treatment (P < 0.05), and the levels of serum IL-6, TNF-α, and CRP in the treatment group were lower than those in the control group (P < 0.05). Conclusion Potassium Sodium Pehydroandroandrographolide Succinate for injection (lyophilized) combined with Ribavirin Injection has a definite therapeutic effect on viral pneumonia, which can effectively alleviate clinical symptoms and inflammatory reactions.

R974

蘇州市吳江區(qū)科教興衛(wèi)項目（WWK201608）