目的 探討十味龍膽花顆粒聯(lián)合硫酸特布他林霧化液治療兒童急性支氣管炎的臨床療效。方法 將2021年7月—2024年5月在山西省兒童醫(yī)院就診的88例急性支氣管炎患兒作為研究對(duì)象，按隨機(jī)數(shù)字表法將所有患兒分為對(duì)照組和治療組，各44例。對(duì)照組通過(guò)霧化器吸入硫酸特布他林霧化液，3次/d，20 kg以下兒童每次吸入半瓶，20 kg及以上兒童每次吸入1瓶。治療組在對(duì)照組基礎(chǔ)上開(kāi)水沖服十味龍膽花顆粒，1袋/次，3次/d。兩組在治療7 d后分析治療效果。比較兩組患兒的主癥狀消失時(shí)間、咳嗽病情、肺通氣功能指標(biāo)、血清炎癥指標(biāo)。結(jié)果 治療組的總有效率明顯高于對(duì)照組（95.45%vs 81.82%，P＜0.05）。治療組發(fā)熱、肺啰音、咳嗽、咯痰消失時(shí)間均短于對(duì)照組（P＜0.05）。治療后，兩組的咳嗽程度評(píng)分表（CET）評(píng)分均顯著減?。?i>P＜0.05），且治療組CET評(píng)分明顯小于對(duì)照組（P＜0.05）。治療后，兩組的第1秒用力呼氣容積（FEV₁）、最大呼氣流量（PEF）均比治療前高（P＜0.05），且治療組FEV₁、PEF較對(duì)照組更高（P＜0.05）。治療后，兩組血清白細(xì)胞介素-2（IL-2）水平高于治療前，血清白細(xì)胞介素-8（IL-8）、鱗狀細(xì)胞癌相關(guān)抗原（SCCA）水平低于治療前（P＜0.05）；治療組血清IL-2水平高于對(duì)照組，血清IL-8、SCCA水平低于對(duì)照組（P＜0.05）。結(jié)論 十味龍膽花顆粒聯(lián)合硫酸特布他林霧化液可提高兒童急性支氣管炎的療效，促進(jìn)患兒癥狀改善，減輕咳嗽程度，改善肺通氣功能，降低炎癥反應(yīng)。

Objective To explore the clinical efficacy of Shiwei Longdanhua Granules combined with Terbutaline Sulphate Solution for nebulization in treatment of acute bronchitis in children. Methods 88 Children with acute bronchitis in Shanxi Children's Hospital from July 2021 to May 2024 were divided into control group and treatment group by random number table method, with 44 cases in each group. Children in the control group inhaled Terbutaline Sulphate Solution for nebulization with a nebulizer, 3 times daily. Children under 20 kg inhaled half a bottle each time, and children over 20 kg inhaled one bottle each time. On the basis of the control group, children in the treatment group were po administered with Shiwei Longdanhua Granules in boiling water, 1 bag/time, 3 times daily. The treatment effect of two groups of children were analyze after 7 d of treatment. The disappearance times of main symptoms, cough condition, pulmonary ventilation function indicators, and serum inflammation indicators between two groups of children were compared. Results The total effective rate of the treatment group was significantly higher than that of the control group (95.45% vs 81.82%, P < 0.05). The disappearance times of fever, pulmonary rales, cough, and sputum in the treatment group was lower than those in the control group (P < 0.05). After treatment, the CET scores of both groups were significantly decreased (P < 0.05), and the CET scores in the treatment group were lower than those in the control group (P < 0.05). After treatment, FEV₁ and PEF of both groups were higher than those before treatment (P < 0.05), and FEV₁ and PEF in the treatment group was higher than those in the control group (P < 0.05). After treatment, the serum levels of IL-2 in both groups were higher than those before treatment, while serum levels of IL-8 and SCCA levels were lower than those before treatment (P < 0.05). The serum levels of IL-2 levels in the treatment group were higher than those in the control group after treatment, while serum levels of IL-8 and SCCA levels were lower than those in the control group (P < 0.05). Conclusion The combination of Shiwei Longdanhua Granules and Terbutaline Sulphate Solution for nebulization can improve the efficacy of acute bronchitis in children, promote symptom improvement, alleviate cough severity, improve lung ventilation function, and reduce inflammatory reactions.

R974;R985