急性胰腺炎是最常見的胃腸道急重癥，由于缺乏特效的藥物，其發(fā)病率和死亡率均較高。大黃素是大黃中的主要有效成分，具有多種藥理作用，可通過降低炎癥反應(yīng)、降低胰腺組織細(xì)胞凋亡、保護(hù)腸道屏障功能、降低氧化應(yīng)激反應(yīng)、調(diào)節(jié)免疫平衡、降低消化酶分泌多途徑、多靶點控制急性胰腺炎的病情發(fā)展，減輕胰腺組織的損傷?？偨Y(jié)了大黃素防治急性胰腺炎的藥理作用研究進(jìn)展，為大黃素的臨床應(yīng)用提供參考。

Acute pancreatitis is the most common gastrointestinal acute and severe disease, but its incidence rate and mortality are high due to the lack of specific drugs. Emodin is the main active ingredient in Rhei Radix et Rhizoma and has various pharmacological effects. Emodin can control the progression of acute pancreatitis and alleviate pancreatic tissue damage by reducing inflammation response, decreasing pancreatic tissue cell apoptosis, protecting intestinal barrier function, reducing oxidative stress response, regulating immune balance, and lowering digestive enzyme secretion through multiple pathways and targets. This article summarizes the research progress on the pharmacological effects of emodin in prevention and treatment of acute pancreatitis, providing reference for the clinical application of emodin.

R975

常州市武進(jìn)區(qū)科技計劃項目(WS201711)