多藥耐藥構成了一種獨特而關鍵的耐藥譜，嚴重影響腫瘤的治療效果。中藥聯(lián)合化療藥物不僅可以降低化療引起的不良反應，還可以增強化療效果，逆轉多藥耐藥。紫草素是從紫草根中提取的萘醌類化合物，具有廣泛的藥理作用。紫草素聯(lián)合順鉑、吉非替尼、奧沙利鉑、阿霉素、紫杉醇、他莫昔芬等化療藥物的療效更顯著，其可通過多種分子機制來降低腫瘤細胞對化療藥物的敏感性。闡述紫草素與多種化療藥物聯(lián)合使用逆轉腫瘤耐藥性的研究進展，以期為臨床克服腫瘤治療耐藥性提供參考。

Multidrug resistance constitutes a unique and critical spectrum of drug resistance, which seriously affects the therapeutic efficacy of tumors. The combination of traditional Chinese medicine and chemotherapy drugs can not only reduce the adverse reactions caused by chemotherapy, but also enhance the efficacy of chemotherapy and reverse multidrug resistance. Shikonin is a naphthoquinone compound extracted from Arnebiae Radix, which has a wide range of pharmacological effects. The combination of shikonin and chemotherapy drugs such as cisplatin, gefitinib, oxaliplatin, doxorubicin, paclitaxel, and tamoxifen has a more significant therapeutic effect, and it can reduce the sensitivity of tumor cells to chemotherapy drugs through various molecular mechanisms. This article summarizes the research progress on shikonin in combination with multiple chemotherapy drugs to reverse tumor resistance, in order to provide reference for overcoming tumor treatment resistance in clinical practice.

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國家自然科學基金資助項目（81402344）；陜西省自然科學基礎研究計劃項目（2023-JC-YB-745）