目的 探討痔寧片聯合地奧司明片治療內痔的臨床效果。方法 選取2021年1月—2022年12月上海市金山區(qū)亭林醫(yī)院收治的98例內痔患者，依據治療方案的不同將98例患者分為對照組和治療組，每組均49例。對照組患者口服地奧司明片，3片/次，2次/d，4 d后改為2片/次，2次/d。治療組患者在對照組基礎上口服痔寧片，3片/次，3次/d。兩組均連續(xù)治療14 d。比較兩組臨床療效、復發(fā)情況、臨床癥狀明顯改善時間、疼痛情況、血清炎癥因子水平。結果 治療后，治療組總有效率高于對照組，復發(fā)率低于治療組，差異有統(tǒng)計學意義（P＜0.05）。治療后，治療組便血、疼痛、脫出、肛門不適改善時間均短于對照組，差異有統(tǒng)計學意義（P＜0.05）。治療后，兩組VAS評分均顯著下降（P＜0.05），且治療組VAS評分低于對照組（P＜0.05）。治療后，兩組血清白細胞介素（IL）-1、腫瘤壞死因子-α（TNF-α）、IL-6水平均顯著下降（P＜0.05），且治療組血清IL-1、TNF-α、IL-6水平均明顯低于對照組（P＜0.05）。結論 痔寧片聯合地奧司明片治療內痔具有顯著的臨床療效，能夠緩解患者臨床癥狀，減輕疼痛，降低炎癥水平和復發(fā)率。

Objective To explore the clinical effect of Zhining Tablets combined with Diosmin Tablets in treatment of internal hemorrhoids. Methods 98 Patients with internal hemorrhoids admitted to Shanghai Jinshan District Tinglin Hospital from January 2021 to December 2022 were selected and divided into control group and treatment group according to different treatment plans, with 49 cases in each group. Patients in the control group were po Diosmin Tablets, 3 tablets/time, 2 times daily. After 4 d, the dosage was changed to 2 tablets/time, 2 times daily. Patients in the treatment group were po Zhining Tablets on the basis of control group, 3 tablets/time, 3 times daily. Both groups received continuous treatment for 14 d. The clinical efficacy, recurrence, improvement time of clinical symptoms, pain, and serum inflammatory factors were compared between two groups. Results After treatment, the total effective rate of the treatment group was higher than that of the control group, and the recurrence rate was lower than that of the treatment group, with statistical significance (P < 0.05). After treatment, the improvement time of hematochezia, pain, prolapse, and anal discomfort in the treatment group was shorter than that in the control group, and the difference was statistically significant (P < 0.05). After treatment, VAS score of both groups was significantly decreased (P < 0.05), and VAS score of the treatment group was lower than that of the control group (P < 0.05). After treatment, serum levels of IL-1, TNF-α, and IL-6 in two groups were significantly decreased (P < 0.05), and serum levels of IL-1, TNF-α, and IL-6 in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion The clinical effect of Zhining Tablets combined with Diosmin Tablets in treatment of internal hemorrhoids is significant, which can significantly alleviate clinical symptoms, improve pain, reduce inflammation levels and recurrence rates.

R982

上海市金山區(qū)衛(wèi)生健康委員會科研課題計劃項目（JSKJ-KTMS-2022-06）