目的 觀察坤泰膠囊聯合氯喹那多–普羅雌烯陰道片治療老年性陰道炎的臨床療效。方法 選取2020年6月—2022年6月無錫市婦幼保健院收治的101例老年性陰道炎患者作為研究對象，根據治療方案不同分為對照組（50例）和治療組（51例）。對照組使用氯喹那多–普羅雌烯陰道片，睡前清潔外陰，佩戴手套，陰道深處塞入氯喹那多–普羅雌烯陰道片，1片/次，1次/d。治療組在對照組基礎上口服坤泰膠囊，4粒/次，3次/d。兩組均治療18 d。比較兩組臨床療效、復發(fā)率、陰道清潔程度、陰道健康水平、性激素水平。結果 治療后，治療組的總有效率較對照組更高（88.24% vs 70.00%），治療組的復發(fā)率低于對照組（17.65% vs 36.00%，P＜0.05）。治療后，兩組患者陰道清潔度正常率均顯著升高（P＜0.05），治療組陰道清潔度正常率高于對照組（P＜0.05）。治療后，兩組陰道健康評分均上升（P＜0.05），且治療組陰道健康評分高于對照組（P＜0.05）。治療后，兩組血清卵泡刺激素（FSH）、黃體生成素（LH）均下降，血清雌二醇（E₂）均上升（P＜0.05），且治療組血清FSH、LH低于對照組，血清E₂較高于對照組（P＜0.05）。結論 坤泰膠囊聯合氯喹那多–普羅雌烯陰道片可有效治療老年性陰道炎，提高陰道健康和清潔程度，改善患者性激素水平。

Objective To observe the clinical efficacy of Kuntai Capsules combined with Chlorquinaldol Promestriene Vaginal Tablets in treatment of senile vaginitis. Methods A total of 101 women with senile vaginitis admitted to Wuxi Maternal and Child Health Hospital from June 2020 to June 2022 were selected as the study objects. According to different treatment plans, women were divided into the control group (50 cases) and treatment group (51 cases). Women in the control group were treated with Chlorquinaldol Promestriene Vaginal Tablets, the vulva was cleaned with water before going to bed every day, and the Chlorquinaldol Promestriene Vaginal Tablets were inserted into the depths of the vagina, 1 tablet/time, once daily. Women in the treatment group were po administered with Kuntai Capsules on the basis of the control group, 4 capsules/time, 3 times daily. Patients were treated for 18 d. The clinical efficacy, recurrence rate, vaginal cleanliness, vaginal health level, and sex hormone level were compared between two groups. Results Compared with control group, the total clinical efficacy rate of the treatment group was significantly higher than that of the control group (88.24% vs 70.00%), and the recurrence rate (36.00%) of the treatment group was significantly lower than 17.65% of the control group (P < 0.05). After treatment, the normal rate of vaginal cleanliness in two groups was significantly increased (P < 0.05). Compared with the control group, the normal rate of vaginal cleanliness in the treatment group was significantly higher than these after treatment, with statistical significant differences (P < 0.05). Compared with the control group, the serum levels of FSH and LH in two group were decreased, while the serum levels of E₂ were increased (P < 0.05), and the serum levels of FSH and LH in treatment group were lower than those in the control group, while the serum levels of E₂ in the treatment group was higher than those in the control group (P < 0.05). Conclusion Kuntai Capsules combined with Chlorquinaldol Promestriene Vaginal Tablets has a good therapeutic effect on senile vaginitis, can improve the health and cleanliness of the vagina, and effectively improve the level of sex hormones.

R984

江蘇省婦幼健康科研項目（F202107）