目的 探討熱毒寧注射液聯(lián)合注射用頭孢唑林鈉治療急性支氣管炎的臨床療效。方法 選取2022年3月—2024年2月宜興市人民醫(yī)院收治的80例急性支氣管炎患者，將所有患者按照隨機數(shù)字表法分為對照組和治療組，40例/組。對照組靜脈滴注注射用頭孢唑林鈉，2次/d，1 g/次，加入200 mL生理鹽水。治療組在對照組基礎(chǔ)上滴注熱毒寧注射液，1次/d，20 mL/次，溶于250 mL生理鹽水。兩組患者持續(xù)治療7 d。比較兩組的臨床療效、癥狀緩解時間、咳嗽頻率、咳嗽程度、小氣道功能指標(biāo)和血清指標(biāo)。結(jié)果 治療后，治療組的總有效率為97.50%，對照組的總有效率為82.50%，組間比較差異有統(tǒng)計學(xué)意義（P＜0.05）。治療后，治療組患者高熱、氣喘、咳嗽、咯痰緩解時間均短于對照組，差異有統(tǒng)計學(xué)意義（P＜0.05）。治療后，兩組的咳嗽頻率、簡易咳嗽程度量表（CET）評分均低于治療前（P＜0.05），且治療組患者的咳嗽頻率、CET評分低于對照組（P＜0.05）。治療后，兩組的用力呼氣50%肺活量時的瞬間流量（FEF_50%）、用力呼出氣量為25%～75%肺活量間的平均流量（FEF_25%-75%）、呼氣高峰流量（PEFR）明顯高于治療前（P＜0.05）；治療組的FEF_50%、FEF_25%-75%、PEFR高于對照組（P＜0.05）。治療后，兩組的血清標(biāo)本淀粉樣蛋白A（SAA）、C反應(yīng)蛋白（CRP）、降鈣素原（PCT）、免疫球蛋白M（IgM）水平均顯著下降（P＜0.05），且治療組血清SAA、CRP、PCT、IgM水平比對照組下降更明顯（P＜0.05）。結(jié)論 熱毒寧注射液聯(lián)合注射用頭孢唑林鈉可提高急性支氣管炎的療效，緩解臨床癥狀，減輕咳嗽，改善小氣道功能，降低炎癥反應(yīng)。

Objective To investigate the clinical efficacy of Reduning Injection combined with Cefazolin Sodium for injection in treatment of acute bronchitis. Methods A total of 80 patients with acute bronchitis admitted to Yixing People’s Hospital from March 2022 to February 2024 were selected and divided into control group and treatment group according to random number table method, with 40 cases/group. Patients in the control group were iv Cefazolin Sodium for injection, twice daily, 1 g/time, and 200 mL normal saline was added. On the basis of the control group, patients in the treatment group were iv Reduning Injection, once daily, 20 mL/time, dissolved in 250 mL normal saline. Both groups were treated for 7 d. The therapeutic effect, symptom remission time, cough frequency, cough degree, small airway function index, and serum index were compared between two groups. Results After treatment, the total effective rate of the treatment group was 97.50%, the total effective rate of the control group was 82.50%, and the difference between groups was statistically significant (P < 0.05). After treatment, the remission time of hyperthermia, asthma, cough, and phlegm in the treatment group was shorter than that in the control group, and the difference was statistically significant (P < 0.05). After treatment, the cough frequency and CET scores of two groups were lower than these before treatment (P < 0.05), and the cough frequency and CET scores of the treatment group were lower than those of the control group (P < 0.05). After treatment, FEF_50%, FEF_25%-75%, and PEFR in two groups were significantly higher than these before treatment (P < 0.05). FEF_50%, FEF_25%-75%, and PEFR in the treatment group were higher than those in the control group (P < 0.05). After treatment, the levels serum of SAA, CRP, PCT, and IgM in two groups were significantly decreased (P < 0.05), and the levels serum of SAA, CRP, PCT, and IgM in the treatment group were more significantly decreased than those in the control group (P < 0.05). Conclusion Reduning Injection combined with Cefazolin Sodium for injection can improve the curative effect of acute bronchitis, relieve clinical symptoms, relieve cough, improve small airway function and reduce inflammation.

R974

宜興市科技（社會發(fā)展）項目（2019SF21）