肝癌是癌癥死亡最常見(jiàn)原因之一，大多數(shù)類(lèi)型的肝癌對(duì)化療具有高度耐藥性。青藤堿是從青藤的根和莖中提取的嗎啡烷型生物堿，具有多種藥理作用，通過(guò)促進(jìn)腫瘤細(xì)胞凋亡、抑制腫瘤細(xì)胞增殖、阻止腫瘤細(xì)胞侵襲和轉(zhuǎn)移、調(diào)節(jié)免疫功能、與抗癌藥物發(fā)揮協(xié)同作用防治肝癌?？偨Y(jié)了青藤堿防治肝癌的藥理作用研究進(jìn)展，希望為青藤堿臨床治療肝癌提供參考。

Liver cancer is one of the most common causes of cancer death, and most types of liver cancer have high resistance to chemotherapy. Sinomenine is a morphine alkaloid extracted from the roots and stems of Cocculus trilopus. (Thunb.) DC. and it has various pharmacological effects. Sinomenine can promote tumor cell apoptosis, inhibit tumor cell proliferation, prevent tumor cell invasion and metastasis, regulate immune function, and has synergistic effects with anti-cancer drugs to prevent and treat liver cancer. This article summarizes the pharmacological research progress of sinomenine in prevention and treatment of liver cancer, hoping to provide reference for the clinical treatment of liver cancer with sinomenine.

R965

新疆維吾爾自治區(qū)區(qū)域協(xié)同創(chuàng)新專(zhuān)項(xiàng)（上海合作組織科技伙伴計(jì)劃及國(guó)際科技合作計(jì)劃）項(xiàng)目（2022E01008）