目的 探討新癀片聯(lián)合鹽酸米諾環(huán)素軟膏治療智齒冠周炎的臨床療效。方法 選取2021年3月—2024年2月在天津市職業(yè)病防治院就診的88例智齒冠周炎患者，按隨機(jī)數(shù)字表法分為對照組和治療組，每組各44例。對照組將鹽酸米諾環(huán)素軟膏注滿患處的牙周袋內(nèi)，1次/周。治療組在對照組基礎(chǔ)上口服新癀片，3次/d，3片/次。兩組患者持續(xù)治療4周。比較兩組的臨床療效、癥狀消失時間、主觀牙痛程度、牙齦指數(shù)和血清炎性指標(biāo)。結(jié)果 治療組的治愈率為95.45%，對照組的治愈率為81.82%，組間差異顯著（P＜0.05）。治療后，治療組患者牙齒腫脹、牙齒疼痛、張口受限、發(fā)熱消失時間均短于對照組（P＜0.05）。治療后，兩組的視覺模擬法（VAS）評分、牙齦指數(shù)、血清超敏C反應(yīng)蛋白（hs-CRP）、前列腺素E₂（PGE₂）水平均低于治療前，血清白細(xì)胞介素-2（IL-2）水平高于治療前（P＜0.05）；治療組的VAS評分、牙齦指數(shù)、血清hs-CRP、PGE₂水平比對照組低，血清IL-2水平高于對照組（P＜0.05）。結(jié)論 新癀片聯(lián)合鹽酸米諾環(huán)素軟膏可提高智齒冠周炎的治療效果，改善臨床癥狀，減輕疼痛程度，改善牙齦狀態(tài)，降低炎癥反應(yīng)。

Objective To explore the clinical efficacy of Xinhuang Tablets combined with Minocycline Hydrochloride Ointment in treatment of wisdom tooth periodontitis. Methods Patients (88 cases) with wisdom tooth pericoronitis treated in Tianjin Occupational Disease Prevention and Therapeutic Hospital from March 2021 to February 2024 were selected and divided into control group and treatment group according to random number table method, with 44 cases in each group. Patients in the control group was filled with Minocycline Hydrochloride Ointment in the periodontal pocket of the affected area, once weekly. In the treatment group, Xinhuang Tablets was taken orally, three times daily, 3 tablets/times on the basis of the control group. Patients of two groups were treated for 4 weeks. The clinical efficacy, symptom disappearance time, subjective toothache degree, gingival index, and serum inflammatory indicators between two groups were compare. Results The cure rate was 95.45% in the treatment group, 81.82% in the control group, and the difference between the two groups was significant (P < 0.05). After treatment, the disappearance times of tooth swelling, tooth pain, mouth opening restriction and fever in the treatment group was shorter than those in the control group (P < 0.05). After treatment, VAS scores, gingival index, and serum levels of hs-CRP and PGE₂ of two groups were lower than those before treatment, but the serum levels of IL-2 were higher than those before treatment (P < 0.05). VAS score, gingival index, and hs-CRP and PGE₂ serum levels in the treatment group were lower than those in the control group, but serum levels of IL-2 in treatment group were higher than those in control group (P < 0.05). Conclusion Xinhuang Tablets combined with Minocycline Hydrochloride Ointment can improve the effect of wisdom tooth pericoronitis, improve clinical symptoms, reduce pain, improve gingival state, and reduce inflammation.

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