目的 探討小兒青翹顆粒聯(lián)合阿莫西林克拉維酸鉀治療小兒急性化膿性扁桃體炎的臨床療效。方法 選擇2021年8月—2023年8月在承德市中心醫(yī)院治療的112例急性化膿性扁桃體炎患兒，依據(jù)用藥情況分為對(duì)照組（56例）和治療組（56例）。對(duì)照組口服阿莫西林克拉維酸鉀片，5歲≤年齡＜7歲，半片/次，7歲≤年齡＜12歲，1片/次，2次/d。在對(duì)照組的基礎(chǔ)上，治療組口服小兒青翹顆粒，5歲≤年齡＜7歲，7.5 g/次，2次/d；7歲≤年齡＜12歲，7.5 g/次，3次/d。兩組用藥治療7 d。觀察兩組患者臨床療效，比較治療前后兩組患者癥狀好轉(zhuǎn)時(shí)間，匹茲堡睡眠指數(shù)量表評(píng)分（PSQI），及血清白細(xì)胞介素1β（IL-1β）、降鈣素原（PCT）、腫瘤壞死因子-α（TNF-α）和白細(xì)胞計(jì)數(shù)（WBC）水平。結(jié)果 治療后，治療組總有效率為96.28%，明顯高于對(duì)照組（83.92%，P＜0.05）。治療后，治療組咽痛、發(fā)熱、扁桃體腫大等癥狀好轉(zhuǎn)時(shí)間均明顯早于對(duì)照組（P＜0.05）。治療后，兩組患兒PSQI評(píng)分明顯下降（P＜0.05），且治療組PSQI評(píng)分明顯低于對(duì)照組（P＜0.05）。治療后，兩組患者血清IL-1β、WBC、TNF-α、PCT水平明顯降低（P＜0.05），且治療組明顯低于對(duì)照組（P＜0.05）。結(jié)論 阿莫西林克拉維酸鉀與小兒青翹顆粒協(xié)同治療，能有效改善患兒扁桃體炎癥狀，明顯改善患兒睡眠質(zhì)量，減弱局部炎性反應(yīng)

Objective To explore the clinical effect of Xiaoer Qingqiao Granules combined with amoxicillin and clavulanate potassium in treatment of acute suppurative tonsillitis in children. Methods Children (112 cases) with acute suppurative tonsillitis from August 2021 to August 2023 were divided into control (56 cases) and treatment (56 cases) group based on different treatments. Children in the control group were po administered with Amoxicillin and Clavulanate Potassium Tablets, 5 years ≤ age < 7 years, half tablet/time, 7 years ≤ age < 12 years, 1 tablet/time, twice daily. Children in the treatment group were po administered with Xiaoer Qingqiao Granules on the basis of the control group, 5 years ≤ age < 7 years, 7.5 g/time, twice daily, 7 years ≤ age < 12 years, 7.5 g/time, 3 times daily. Children in two groups were treated for 7 d. After treatment, the clinical evaluations were evaluated, the symptom relief time, the PSQI scores, the levels of serum IL-1β, WBC, TNF-α and PCT in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 96.28%, which was significantly higher than that of the control group (83.92%, P < 0.05). After treatment, the improvement time of symptoms such as sore throat, fever and enlarged tonsil in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the PSQI score in two groups was significantly decreased (P < 0.05), and the score in the treatment group was significantly lower than that of the control group (P < 0.05). After treatment, the serum levels of IL-1β, WBC, TNF-α and PCT in two groups were significantly decreased (P < 0.05), which in the treatment group were significantly lower than that in the control group (P < 0.05). Conclusion The synergistic treatment of Amoxicillin and Clavulanate Potassium Tablets and Xiaoer Qingqiao Granules can effectively improve the symptoms of tonsillitis,significantly improve the sleep quality and weaken the local inflammatory reaction.

R985

河北省醫(yī)學(xué)科學(xué)研究重點(diǎn)課題計(jì)劃項(xiàng)目（20210729）；承德市科技支撐計(jì)劃項(xiàng)目（202201A006）