目的 探討全杜仲膠囊聯(lián)合阿侖膦酸鈉治療老年骨質(zhì)疏松癥的臨床療效。方法 選擇2020年3月—2023年8月在西電集團(tuán)醫(yī)院治療的98例老年骨質(zhì)疏松癥患者，根據(jù)隨機(jī)數(shù)表法分為對照組（49例）和治療組（49例）。對照組早餐前30 min口服阿侖膦酸鈉片，10 mg/次，1次/d。治療組在對照組基礎(chǔ)上口服全杜仲膠囊，2粒/次，2次/d。兩組均治療3個月。觀察兩組患者臨床療效，比較治療前后兩組患者中醫(yī)癥狀改善時間，骨代謝指標(biāo)Ⅰ型膠原交聯(lián)C端肽（CTX）、腫瘤壞死因子-α（TNF-α）和尿Ⅰ型膠原交聯(lián)N端肽（NTX）水平，及骨密度水平。結(jié)果 治療后，治療組總有效率為95.92%，比對照組的81.63%明顯升高（P＜0.05）。與對照組比較，治療組患者食少便溏、腰膝冷痛、畏寒喜暖、腰膝酸軟改善時間明顯縮短（P＜0.05）。與治療前比較，兩組血清CTX、TNF-α及NTX水平明顯降低（P＜0.05），且治療組血清CTX、TNF-α和NTX水平更低（P＜0.05）。與治療前比較，兩組股骨頸、腰椎等部位的骨密度均升高（P＜0.05），且與對照組比較，治療組骨密度更高（P＜0.05）。結(jié)論 全杜仲膠囊聯(lián)合阿侖膦酸鈉治療老年骨質(zhì)疏松癥可快速改善患者的中醫(yī)癥狀、增加骨密度水平、有效調(diào)節(jié)骨代謝指標(biāo)。

Objective To explore the therapeutic effect of Quanduzhong Capsules combined with alendronate sodium in treatment of elderly osteoporosis. Methods Patients (98 cases) with elderly osteoporosis in XD Group Hospital from March 2020 to August 2023 were divided into control (49 cases) and treatment (49 cases) group according to the random number table method. Patients in the control group were po administered with Alendronate Sodium Tablets 30 min before breakfast, 10 mg/time, once daily. Patients in the treatment group were po administered with Quanduzhong Capsules on the basis of the control group, 2 grains/time, twice daily. Patients in two groups were treated for 3 months. After treatment, the clinical evaluations were evaluated, the improvement time of TCM symptoms, the levels of bone metabolism indicators CTX, TNF-α and NTX, and bone density levels in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 95.92%, which was significantly higher than that of the control group (81.63%, P < 0.05). Compared with the control group, the improvement time of loose stool, cold pain of waist and knees, fear of cold and warmth, sore waist and knees in the treatment group was significantly shorter than that in the control group (P < 0.05). The levels of serum CTX, TNF-α and NTX in two groups were significantly lower than those before treatment (P < 0.05), and the levels of serum CTX, TNF-α and NTX in the treatment group were lower than those before treatment (P < 0.05). Compared with those before treatment, the bone mineral density of femoral neck and lumbar vertebrae in two groups was significantly increased (P < 0.05), and the bone mineral density in the treatment group was higher than that in the control group (P < 0.05). Conclusion Quanduzhong Capsules combined with alendronate sodium combined with alendronate can quickly improve the TCM symptoms, increase the level of bone mineral density and effectively regulate bone metabolism.

R982

陜西省衛(wèi)生健康科研項目（2022D017）