目的 對(duì)亳州市人民醫(yī)院納洛酮使用進(jìn)行合理性評(píng)價(jià)，促進(jìn)臨床合理使用納洛酮。方法 以納洛酮說(shuō)明書為基礎(chǔ)，結(jié)合相關(guān)指南、專家共識(shí)及文獻(xiàn)，建立納洛酮藥物利用評(píng)價(jià)（DUE）細(xì)則，并以此為依據(jù)，運(yùn)用屬性層次模式的方法對(duì)亳州市人民醫(yī)院2023年1月1日—2023年12月1日納洛酮的使用情況進(jìn)行合理性評(píng)價(jià)。結(jié)果 在評(píng)價(jià)的151份病歷中，優(yōu)秀病歷占比2.65%，良好病歷28.48%，合格64.90%，不合格3.97%，不合理應(yīng)用主要表現(xiàn)在適應(yīng)證不合理、用量不合理、療程不合理和無(wú)用藥監(jiān)測(cè)。結(jié)論 評(píng)價(jià)結(jié)果反映納洛酮在臨床使用中存在的不合理現(xiàn)象，需進(jìn)一步加強(qiáng)管控。

Objective To evaluate the rationality of naloxone use in Bozhou People’s Hospital, and promote the rational use of naloxone in clinical practice. Methods The naloxone drug utilization evaluation (DUE) rules were established based on the naloxone instruction manual, combined with related guidelines, expert consensus and literature. Based on this, the use of naloxone in Bozhou People’s Hospital from January 1, 2023 to December 1, 2023 was rationally evaluated by using attribute hierarchy model. Results Among the 151 medical records evaluated, excellent medical records accounted for 2.65%, good medical records 28.48%, qualified 64.90%, and unqualified 3.97%. Irrational use was mainly manifested in unreasonable indications, unreasonable dosage, unreasonable course of treatment, and no drug monitoring. Conclusion The evaluation results reflect the unreasonable phenomenon in the clinical use of naloxone, which needs to be further strengthened.

R971

安徽省高等學(xué)?？茖W(xué)研究項(xiàng)目（自然科學(xué)類）（2023AH053213）