結直腸癌具有較高的發(fā)病率和病死率，藥物治療可延長生存期，但會出現(xiàn)不同程度的耐藥。β-欖香烯是從溫郁金中提取的活性成分，具有廣譜的抗腫瘤活性，可抑制腫瘤細胞生長和增殖、誘導腫瘤細胞凋亡、抑制腫瘤細胞侵襲和轉移、逆轉腫瘤藥物耐藥、聯(lián)合化療增效減毒、同步放療增敏、改善免疫功能。綜述了β-欖香烯治療結直腸癌的作用機制研究進展，以期為β-欖香烯臨床治療結直腸癌提供參考。

Colorectal cancer has a high incidence rate and mortality. Drug treatment can prolong the survival period of patients, but there will be different degrees of drug resistance. β-Elemene is an active ingredient extracted from Curcumae Radix, which has a broad-spectrum anti-tumor activity. It can inhibit the growth and proliferation of tumor cells, induce tumor cell apoptosis, inhibit tumor cell invasion and metastasis, reverse tumor drug resistance, enhance the efficacy and toxicity of combined chemotherapy, increase sensitization with simultaneous radiotherapy, and improve immunization. This article provides an overview of research progress on mechanism of β-elemene in treatment of colorectal cancer, hoping to provide reference for β-elemene in clinical treatment of colorectal cancer.

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吳階平醫(yī)學基金會臨床科研專項（HK8203521）