目的 探討雷公藤多苷片聯(lián)合曲安奈德口腔軟膏治療盤狀紅斑狼瘡的臨床療效。方法 選取2021年1月—2023年5月唐山市人民醫(yī)院收治的94例盤狀紅斑狼瘡患者，根據(jù)隨機(jī)數(shù)字表法將94例患者分為對(duì)照組和治療組，各47例。對(duì)照組于早飯后、晚餐后涂抹曲安奈德口腔軟膏，0.4 g/次，2次/d，涂抹后1 h內(nèi)禁食禁飲。治療組在對(duì)照組基礎(chǔ)上飯后口服雷公藤多苷片，1～1.5 mg/kg，3次/d。兩組持續(xù)治療4周。比較兩組臨床療效、主觀疼痛程度、病灶面積和血清因子水平。結(jié)果 治療后，對(duì)照組總有效率為78.72%，治療組總有效率為93.62%，組間比較差異顯著（P＜0.05）。治療后，兩組視覺模擬法（VAS）評(píng)分比治療前小，病損面積顯著縮小（P＜0.05），且治療組VAS評(píng)分比對(duì)照組更小，治療組病損面積小于對(duì)照組（P＜0.05）。治療后，兩組的血清白細(xì)胞介素-2（IL-2）水平高于治療前，血清骨橋蛋白（OPN）、白細(xì)胞介素-6（IL-6）水平低于治療前（P＜0.05）；治療組的血清IL-2水平高于對(duì)照組，血清OPN、IL-6水平低于對(duì)照組（P＜0.05）。結(jié)論 雷公藤多苷片聯(lián)合曲安奈德口腔軟膏可提高盤狀紅斑狼瘡的療效，有助于減輕疼痛程度和縮小病損面積，減輕炎癥反應(yīng)。

Objective To investigate the curative effect of Tripterygium Glycosides Tablets combined with Triamcinolone Acetonide Dental Paste in treatment of discoid lupus erythematosus. Methods Patients (94 cases) with discoid lupus erythematosus in Tangshan People’s Hospital from January 2021 to May 2023 were divided into control and treatment groups according to the random number table method, and each group had 47 cases. Patients in the control group were treated with Triamcinolone Acetonide Dental Paste after breakfast and dinner, 0.4 mg/time, twice daily, abstained from food and drink within 1 h after application. Patients in the treatment group were po administered with Tripterygium Glycosides Tablets on the basis of the control group, 1 — 1.5 mg/time, three times daily. Patients in two groups were treated for 4 weeks. The clinical efficacies, the subjective pain degree, lesion area, and serum factor levels in two groups were compared. Results After treatment, the total effective rate of the control group was 78.72%, but the total effective rate of the treatment group was 93.62%, and the difference between the groups was significant (P < 0.05). After treatment, VAS score of two groups was smaller than before treatment, and the lesion area of two groups was significantly reduced (P < 0.05), and the VAS score of the treatment group was smaller than that of the control group, and the lesion area of the treatment group was smaller than that of the control group (P < 0.05). After treatment, the levels of IL-2 in two groups were higher than before treatment, but the levels of OPN and IL-6 in two groups were lower than before treatment (P < 0.05). After treatment, the levels of IL-2 in the treatment group were higher than those in the control group, but the levels of OPN and IL-6 in the treatment group were lower than those in the control group (P < 0.05). Conclusion Tripterygium Glycosides Tablets combined with Triamcinolone Acetonide Dental Paste can improve the curative effect of discoid lupus erythematosus, help to reduce the degree of pain, lesion area, and inflammation.

R988.2

河北省衛(wèi)生健康委醫(yī)學(xué)科學(xué)研究課題計(jì)劃（20181210）