目的 探討穩(wěn)心顆粒聯(lián)合鹽酸維拉帕米注射液治療陣發(fā)性室上性心動過速的臨床療效。方法 選取2021年7月—2023年6月在首都醫(yī)科大學附屬北京康復醫(yī)院就診的116例陣發(fā)性室上性心動過速患者，按隨機數(shù)字表法分為對照組和治療組，每組各58例。對照組靜脈推注鹽酸維拉帕米注射液，將5 mg鹽酸維拉帕米注射液加入10 mL生理鹽水，3 min內(nèi)靜脈推注，觀察20 min，若病情未好轉(zhuǎn)，重復注射直至轉(zhuǎn)復后停止，每日劑量不超過50 mg。治療組在對照組治療基礎(chǔ)上開水沖服穩(wěn)心顆粒，1袋/次，3次/d。兩組療程均為4周。比較兩組的臨床療效、發(fā)作和治療情況、超聲心電圖檢查和心功能指標。結(jié)果 治療組的總有效率為93.10%，明顯高于對照組的總有效率79.31%，差異有統(tǒng)計學意義（P＜0.05）。治療后，治療組的發(fā)作頻次、平均轉(zhuǎn)復時間低于治療前，30 min內(nèi)轉(zhuǎn)復率高于治療前（P＜0.05）；治療組的發(fā)作頻次、平均轉(zhuǎn)復時間低于對照組，30 min內(nèi)轉(zhuǎn)復率高于對照組（P＜0.05）。治療后，治療組患者的短陣室速數(shù)、室性期前收縮數(shù)比治療前小（P＜0.05），且比對照組的短陣室速數(shù)、室性期前收縮數(shù)更?。?i>P＜0.05）。治療后，治療組的左心室射血分數(shù)（LVEF）比治療前大，左心室收縮末期容積（LVESV）比治療前?。?i>P＜0.05）；治療組患者的LVEF比對照組大，LVESV比對照組小（P＜0.05）。結(jié)論 穩(wěn)心顆粒聯(lián)合鹽酸維拉帕米注射液可提高陣發(fā)性室上性心動過速的臨床療效，減輕發(fā)作頻率，改善心功能。

Objective To investigate the effect of Wenxin Granules combined with Verapamil Hydrochloride Injection in treatment of paroxysmal supraventricular tachycardia. Methods Patients (116 cases) with paroxysmal supraventricular tachycardia in Beijing Rehabilitation Hospital Affiliated to Capital Medical University from July 2021 to June 2023 were divided into control and treatment groups according to the random number table method, and each group had 58 cases. Patients in the control group were iv administered with Verapamil Hydrochloride Injection, 5 mg drug added into normal saline 10 mL, iv within 3 min, observing for 20 min. If the condition did not improve, repeating the injection until recovery and stop. The daily dose did not exceed 50 mg. Patients in the treatment group were po administered with Wenxin Granules with boiling water on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies, attack and treatment status, ultrasound electrocardiogram examination, and cardiac function indicators in two groups were compared. Results The total effective rate of the treatment group was 93.10%, which was significantly higher than 79.31% of the control group, and the difference was statistically significant (P < 0.05). After treatment, the attack frequency and average recovery time in the treatment group were lower than those before treatment, but the recovery rate within 30 min in the treatment group was higher than that before treatment (P < 0.05). The frequency of attack and the mean recovery time of treatment group were lower than that of control group, but the recovery rate within 30 min of treatment group was higher than that of control group (P < 0.05). After treatment, the number of short ventricular tachycles and the number of pre-ventricular contractions in the treatment group was smaller than those before treatment (P < 0.05), and the number of short ventricular tachycles and the number of pre-ventricular contractions in the treatment group was smaller than those in the control group (P < 0.05). After treatment, LVEF in two groups were significantly higher than those before treatment, but LVESV was significantly decreased (P < 0.05). After treatment, LVEF in the treatment group were higher than those before treatment, but LVESV in the treatment group were lower than those in the control group (P < 0.05). Conclusion Wenxin Granule combined with Verapamil Hydrochloride Injection can improve the therapeutic effect of paroxysmal supraventricular tachycardia, reduce the frequency of attacks, and improve cardiac function.

R972

首都衛(wèi)生發(fā)展科研專項項目（2022-3-2254）