結(jié)腸炎是多種因素引起的結(jié)腸炎癥性病變,發(fā)病率逐年上升,病程冗長,有并發(fā)結(jié)腸癌風(fēng)險(xiǎn)。黃芩苷是黃芩中重要的黃酮類化合物之一,可通過降低炎癥反應(yīng)、抗氧化應(yīng)激反應(yīng)、調(diào)節(jié)細(xì)胞凋亡、調(diào)節(jié)腸道菌群、調(diào)節(jié)細(xì)胞自噬等多種途徑發(fā)揮抗結(jié)腸炎作用。歸納了黃芩苷防治結(jié)腸炎的作用機(jī)制研究進(jìn)展,為黃芩苷的臨床應(yīng)用提供參考。

Colitis is a pathological change of colitis caused by many factors. Its incidence rate is increasing year by year, its course is long, and there is a risk of colon cancer. Baicalin is one of the important flavonoid compounds in Scutellariae Radix. Baicalin can play a preventive and therapeutic role in colitis by reducing inflammatory action, antioxidant stress action, regulating cell apoptosis, regulating intestinal microbiota, and regulating cell autophagy. This article summarizes the research progress on the mechanism of baicalin in prevention and treatment colitis, providing reference for the clinical application of baicalin.

R285;R975

濰坊市科技發(fā)展計(jì)劃（軟科學(xué)）項(xiàng)目（2023RKX101）