過敏性皮膚病具有慢性、復(fù)發(fā)性特點(diǎn),需長期接受藥物治療,但可引起不同程度不良反應(yīng),且停藥后癥狀易復(fù)發(fā)。氧化苦參堿是苦參、槐花中主要活性成分,通過抑制肥大細(xì)胞活化、調(diào)節(jié)淋巴細(xì)胞增殖、調(diào)節(jié)Th1/Th2的平衡、調(diào)節(jié)輔助T細(xì)胞17/調(diào)節(jié)T細(xì)胞平衡、調(diào)節(jié)細(xì)胞因子信號(hào)傳導(dǎo)抑制因子1的表達(dá)、下調(diào)瞬時(shí)受體電位通道蛋白A1和瞬時(shí)受體電位通道蛋白V1的表達(dá)、抑制絲裂原活化蛋白激酶/蛋白激酶B信號(hào)通路激活多途徑多靶點(diǎn)防治過敏性皮膚病。綜述了氧化苦參堿治療過敏性皮膚病的作用機(jī)制,為氧化苦參堿的臨床使用提供依據(jù)。

Allergic skin diseases have chronic and recurrent characteristics, and patients need long-term treatment, but can cause varying degrees of adverse reactions, and symptoms are prone to recurrence after discontinuation of medication. Oxymatrine is the main active ingredient in Sophorae Flavescentis Radix and Sophorae Flos. Oxymatrine can prevent and treat allergic skin diseases through multiple pathways and targets through inhibiting mast cell activation, regulating lymphocyte proliferation, regulating Th1/Th2 balance, regulating Th17/Treg balance, regulating the expression of cytokine signaling inhibitory factor 1, down-regulating the expression of TRPA1 and TRPV1, and inhibiting the activation of MAPK/Akt signaling pathway. This article reviews the mechanism of action of oxymatrine in treatment of allergic skin diseases, providing a basis for the clinical use of oxymatrine.

R285;R986

廣東省普通高校特色創(chuàng)新類項(xiàng)目（2023KTSCX041）