目的 探討結(jié)石通膠囊聯(lián)合氨芐西林治療尿路感染的臨床療效。方法 選取2020年7月-2023年6月蚌埠市第一人民醫(yī)院收治的86例尿路感染患者,按隨機(jī)數(shù)字表法將患者分為對(duì)照組和治療組,每組各43例。對(duì)照組口服氨芐西林膠囊,3粒/次,3次/d。治療組在對(duì)照組基礎(chǔ)上口服結(jié)石通膠囊,4粒/次,3次/d。兩組療程均為7 d。觀察兩組臨床療效,比較兩組退熱時(shí)間、尿細(xì)菌培養(yǎng)轉(zhuǎn)陰時(shí)間及治療前后典型癥狀評(píng)分、36項(xiàng)健康調(diào)查簡(jiǎn)表(SF-36)評(píng)分和血清C反應(yīng)蛋白(CRP)、降鈣素原(PCT)、白細(xì)胞介素-6(IL-6)水平。結(jié)果 治療后,治療組總有效率是97.67%,較之對(duì)照組的81.40%顯著提高(P<0.05)。治療后,兩組尿痛評(píng)分、尿頻評(píng)分、尿急評(píng)分、小腹不適評(píng)分均較同組治療前顯著降低(P<0.05);治療后,治療組典型癥狀評(píng)分低于對(duì)照組(P<0.05)。治療組退熱時(shí)間、尿細(xì)菌培養(yǎng)轉(zhuǎn)陰時(shí)間均顯著短于對(duì)照組(P<0.05)。治療后,兩組SF-36評(píng)分均顯著增加,而血清CRP、PCT、IL-6水平均顯著下降(P<0.05);且治療后,治療組SF-36評(píng)分高于對(duì)照組,血清CRP、PCT、IL-6水平低于對(duì)照組(P<0.05)。結(jié)論 結(jié)石通膠囊聯(lián)合氨芐西林治療尿路感染效果確切,可明顯改善生活質(zhì)量,同時(shí)能有效控制尿路感染癥狀,縮短尿細(xì)菌培養(yǎng)轉(zhuǎn)陰時(shí)間,緩解機(jī)體炎癥反應(yīng),值得臨床推廣應(yīng)用。

Objective To explore the clinical efficacy of Jieshitong Capsules combined with ampicillin in treatment of urinary tract infection. Methods A total of 86 patients with urinary tract infection admitted to Bengbu First People's Hospital from July 2020 to June 2023 were selected and divided into control group and treatment group according to random number table method, with 43 cases in each group. Patients in the control group were po administered with Ampicillin Capsules, 3 grains/time, three times daily. Patients in the treatment group were po administered with Jieshitong Capsules on the basis of control group, 4 grains/time, 3 times daily. The treatment course of both groups was 7 d. After treatment, the clinical efficacy was evaluated, and the time for fever reduction, the time for urine bacterial culture to turn negative, and the typical symptom scores before and after treatment, as well as the scores of 36 health survey questionnaires (SF-36) and serum C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6) levels were compared. Results After treatment, the total effective rate of the treatment group was 97.67%, which was significantly higher than that of the control group (81.40%) (P < 0.05). After treatment, the scores of urinalgia, frequency of urination, urgency of urination, and lower abdominal discomfort in 2 groups were significantly lower than before treatment (P < 0.05). After treatment, the typical symptom score of the treatment group was lower than that of control group (P < 0.05). The time of febrile degeneration and the time of urine bacterial culture turning negative in treatment group were significantly shorter than those in control group (P < 0.05). After treatment, SF-36 scores in both groups were significantly increased, but serum CRP, PCT, and IL-6 levels were significantly decreased (P < 0.05). After treatment, the SF-36 score of treatment group was higher than that of control group, but the levels of serum CRP, PCT and IL-6 were lower than those of the control group (P < 0.05). Conclusion Jieshitong Capsules combined with ampicillin has the exact effect in treatment of urinary tract infection, and can significantly improve the life quality, and can effectively control the symptoms of urinary tract infection, shorten the time of urinary bacterial culture to negative, relieve the body inflammatory response, which is worthy of clinical application.

R983

新疆維吾爾自治區(qū)自然科學(xué)基金資助項(xiàng)目（2017D01C102）