卵巢癌是第2大普遍存在的婦科惡性腫瘤，具有較高的死亡率。化療是卵巢癌主要的治療手段，但大多數(shù)患者會(huì)發(fā)生化療耐藥性。雷公藤甲素是從雷公藤中提取的天然活性二萜類(lèi)化合物，具有多種藥理活性。雷公藤甲素可以通過(guò)抑制腫瘤細(xì)胞增殖、促進(jìn)腫瘤細(xì)胞凋亡、降低卵巢癌侵襲力、降低卵巢癌對(duì)順鉑耐藥性、調(diào)節(jié)卵巢癌細(xì)胞周期、增強(qiáng)抗腫瘤免疫應(yīng)答、改變腫瘤微環(huán)境發(fā)揮多途徑防治卵巢癌。歸納了雷公藤甲素防治卵巢癌的作用機(jī)制，為卵巢癌的臨床治療提供依據(jù)。

Ovarian cancer is the second most common gynecological malignancy with a high mortality rate. Chemotherapy is the main treatment for ovarian cancer, but most patients will develop chemotherapy resistance. Tripterygiolide is a naturally active diterpenoid compound extracted from Tripterygii Wilfordii Radix et Rhizoma, with various pharmacological activities. Triptolide can play a multiple pathways to prevent and treat ovarian cancer by inhibiting tumor cell proliferation, promoting cell apoptosis, reducing invasiveness of ovarian cancer, reducing tumor cell resistance against cisplatin, regulating ovarian cancer cell cycle, enhancing anti-tumor immune response, and altering the tumor microenvironment. This article summarizes the mechanism of triptolide in prevention and treatment of ovarian cancer, providing a basis for the clinical treatment for ovarian cancer.

R285;R984

河北省衛(wèi)生和計(jì)劃生育委員會(huì)科研項(xiàng)目（20171027）