目的 建立術(shù)后用地佐辛注射液合理性評價標準，分析其不合理用藥情況，為臨床合理、規(guī)范應(yīng)用該藥物提供參考依據(jù)。方法 參考藥品說明書、專家共識和指南等制定術(shù)后用地佐辛注射液合理性評價細則，隨機抽取安徽醫(yī)科大學(xué)附屬亳州醫(yī)院2023年1～6月科室用藥頻度（DDDs）排名前5位的252例術(shù)后用地佐辛注射液的病歷，應(yīng)用屬性層次模型（AHM）對其進行合理性評價。結(jié)果 252例病歷中，病歷評分（MRS）≥90分的優(yōu)秀病歷103例（占40.87%），75分≤MRS＜90分的良好病歷12例（占4.76%），60分≤MRS＜75分的合格病歷41例（占16.27%）以及MRS＜60分的不合格病歷96例（占38.10%）。不合理類型主要表現(xiàn)為無適應(yīng)證48例次（占28.40%），用法用量43例次（占25.44%），用藥療程36例次（占21.30%），特殊人群用藥22例次（占13.02%），聯(lián)合用藥10例次（占5.92%）及禁忌證5例次（2.96%）。結(jié)論 基于AHM法制定的術(shù)后用地佐辛注射液評價方法切實可行，評價結(jié)果顯示安徽醫(yī)科大學(xué)附屬亳州醫(yī)院術(shù)后用地佐辛注射液不合理用藥情況較差，醫(yī)院應(yīng)進一步加強其醫(yī)囑點評、用藥管理，提高臨床用藥合理性。

Objective To establish rational evaluation standard of postoperative use of Dizocine Injection, and the unreasonable drug use was analyzed to provide a reference for the rational clinical application of this drug. Methods To formulate the rational dosing evaluation system based on drug specification, expert recommendations, guidelines, and other relevant documents. The medical records of 252 patients with postoperative Dizocine Injection, who ranked the top 5 in department use frequency (DDDs) in Bozhou Hospital affiliated to Anhui Medical University from January to June 2023, were randomly selected, and the rationality of them was evaluated by attribute hierarchy model (AHM). Results Among the 252 medical records, 103 excellent medical records (40.87%) had a medical record score (MRS) ≥ 90, and 12 good medical records (4.76%) had a medical record score of 75≤ MRS＜90. There were 41 qualified medical records (16.27%) with 60 ≤ MRS＜75 scores, and 96 unqualified medical records (38.10%) with MRS＜60 scores. The irrational type mainly showed no indication 48 times (28.40%), usage and dosage 43 times (25.44%), treatment course 36 times (21.30%), special population 22 times (13.02%), combined use 10 times (5.92%) and contraindication 5 times (2.96%). Conclusion The evaluation method of Dizocine Injection for postoperative use formulated based on AHM method is feasible, and the evaluation results show that the situation of irrational use of Dizocine Injection for postoperative use in Bozhou Hospital affiliated to Anhui Medical University is poor. The hospital should further strengthen its medical order comments and medication management to improve the rationality of clinical use.

R971

安徽省重點研究與開發(fā)計劃項目（2022e07020066）；安徽醫(yī)科大學(xué)校科研基金項目（2021xkj095）