目的 探析康復(fù)新液聯(lián)合注射用生長(zhǎng)抑素治療急性十二指腸潰瘍出血的臨床效果。方法 選取2020年1月—2022年1月中國(guó)人民解放軍南部戰(zhàn)區(qū)總醫(yī)院診治的106例急性十二指腸潰瘍出血患者，以隨機(jī)數(shù)字表法將所有患者分為對(duì)照組和治療組，各53例。對(duì)照組首先緩慢靜脈注射0.25 mg注射用生長(zhǎng)抑素作為負(fù)荷劑量，而后立即靜脈點(diǎn)滴0.25 mg/h。如果兩次輸液給藥間隔大于3～5 min，采取重新靜脈注射0.25 mg注射用生長(zhǎng)抑素以確保給藥的連續(xù)性。治療組在對(duì)照組治療的基礎(chǔ)上口服康復(fù)新液，10 mL/次，3次/d。兩組連續(xù)治療7 d。比較兩組的臨床療效、臨床指標(biāo)、血清炎性因子水平。結(jié)果 治療后，治療組總有效率為98.11%，顯著高于對(duì)照組的總有效率83.02%（P＜0.05）。治療后，治療組大便隱血轉(zhuǎn)陰時(shí)間、禁食時(shí)間均短于對(duì)照組（P＜0.05）。治療后，兩組血清白細(xì)胞介素-6（IL-6）水平均較治療前下降（P＜0.05）；且治療組的血清IL-6水平均低于對(duì)照組（P＜0.05）。結(jié)論 康復(fù)新液聯(lián)合注射用生長(zhǎng)抑素治療急性十二指腸潰瘍出血的效果更顯著，可有效改善臨床癥狀、降低血清IL-6水平。

Objective To explore the clinical effect of Kangfuxin Solution combined with Somatostatin for injection in treatment of acute duodenal ulcer bleeding. Methods Patients (106 cases) with acute duodenal ulcer bleeding in the General Hospital of the Southern Theater Command of the Chinese People’s Liberation Army from January 2020 to January 2022 were divided into control and treatment groups according to the random number table, and each group had 53 cases. Patients in the control group were first slowly injected with 0.25 mg Somatostatin for injection as loading dose, and then immediately intravenous dripped 0.25 mg/h. If the interval between infusion and infusion was greater than 3 to 5 minutes, 0.25 mg Somatostatin for injection was re-administered intravenously to ensure continuity of administration. Patients in the treatment group were po administered with Kangfuxin Solution on the basis of the control group, 10 mL/time, three times daily. Patients in two groups were treated for 7 d. The clinical efficacies, the changes of clinical indexes, and inflammatory factor levels in two groups were compared. Results Compared with the control group (83.02%), total effective rate of the treatment group (98.11%) was significantly higher (P＜0.05). Compared with control group, time of stool occult blood turning negative and fasting in the treatment group were shorter (P＜0.05). After treatment, the serum levels of IL-6 in two groups decreased compared to before treatment (P＜0.05), and those in the treatment group were lower than those in the control group (P＜ 0.05). Conclusion Kangfuxin Solution combined with Somatostatin for injection has a more significant effect on the treatment of acute duodenal ulcer bleeding, which can effectively improve clinical symptoms and reduce the serum level of IL-6.

R975

廣東省醫(yī)學(xué)科學(xué)技術(shù)研究基金項(xiàng)目（B2022070）